(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride

Base Information

Chemical Name:(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride
CAS No.:1092851-38-1
Molecular Formula:C₂₂H₂₃ClN₂O₃*ClH
Molecular Weight:435.35
Hs Code.:

Synonyms:(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride

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Chemical Property of (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride

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Technology Process of (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride

There total 3 articles about (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1093058-32-2
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane

: 1092851-38-1
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at 20 ℃;

Reference yield:

: 143327-63-3
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(p-toluenesulfonyloxy)methyl]-1,3-dioxalane

: 1092851-38-1
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 8 h / 90 °C

2: hydrogenchloride / water; isopropyl alcohol / 20 °C

With hydrogenchloride; caesium carbonate; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 82362-50-3
4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone

: 1092851-38-1
(2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-(phenoxymethyl)-1,3-dioxolane hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / toluene; butan-1-ol / 8 h / Heating / reflux

2: caesium carbonate / N,N-dimethyl-formamide / 8 h / 90 °C

3: hydrogenchloride / water; isopropyl alcohol / 20 °C

With hydrogenchloride; caesium carbonate; toluene-4-sulfonic acid; In water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; butan-1-ol;