C₂₂H₃₂ClN₃O₂Si

Base Information

Chemical Name:C₂₂H₃₂ClN₃O₂Si
CAS No.:945469-31-8
Molecular Formula:C₂₂H₃₂ClN₃O₂Si
Molecular Weight:434.053
Hs Code.:

C<sub>22</sub>H<sub>32</sub>ClN<sub>3</sub>O<sub>2</sub>Si

Synonyms:C₂₂H₃₂ClN₃O₂Si

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Chemical Property of C₂₂H₃₂ClN₃O₂Si

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Technology Process of C₂₂H₃₂ClN₃O₂Si

There total 12 articles about C₂₂H₃₂ClN₃O₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 573768-09-9
4-amino-2-chloro-3-methyl-benzonitrile

: 945469-31-8
C₂₂H₃₂ClN₃O₂Si

Guidance literature:: Multi-step reaction with 4 steps

1: 39 percent / CuI; tert-butylnitrite / acetonitrile / 3 h / 65 °C

2: 21 percent / Cs₂CO₃ / Pd₂(dba)3; chiral ferrocenyl catalyst / toluene; dimethylsulfoxide / 48 h / 100 °C

3: TFA / CH₂Cl₂ / 3 h / 20 °C

4: 130 mg / i-Pr₂NEt / tetrahydrofuran; toluene / 1.17 h / 0 - 20 °C

With copper(l) iodide; tert.-butylnitrite; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; chiral ferrocenyl catalyst; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/jm070312d

Reference yield:

: 627531-48-0
N-(3-chloro-4-cyano-2-methylphenyl)acetamide

: 945469-31-8
C₂₂H₃₂ClN₃O₂Si

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / conc. HCl; EtOH / 0.5 h / Heating

2: 39 percent / CuI; tert-butylnitrite / acetonitrile / 3 h / 65 °C

3: 21 percent / Cs₂CO₃ / Pd₂(dba)3; chiral ferrocenyl catalyst / toluene; dimethylsulfoxide / 48 h / 100 °C

4: TFA / CH₂Cl₂ / 3 h / 20 °C

5: 130 mg / i-Pr₂NEt / tetrahydrofuran; toluene / 1.17 h / 0 - 20 °C

With hydrogenchloride; copper(l) iodide; tert.-butylnitrite; ethanol; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; chiral ferrocenyl catalyst; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; acetonitrile;
DOI:10.1021/jm070312d

Reference yield:

: 945469-28-3
C₁₈H₃₆N₂O₄Si

: 945469-31-8
C₂₂H₃₂ClN₃O₂Si

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / H₂ / Raney Ni; Pd/C / methanol; H₂O / 20 °C / 4137.29 Torr

2: 21 percent / Cs₂CO₃ / Pd₂(dba)3; chiral ferrocenyl catalyst / toluene; dimethylsulfoxide / 48 h / 100 °C

3: TFA / CH₂Cl₂ / 3 h / 20 °C

4: 130 mg / i-Pr₂NEt / tetrahydrofuran; toluene / 1.17 h / 0 - 20 °C

With hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; chiral ferrocenyl catalyst; nickel; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene;
DOI:10.1021/jm070312d