tert-butyl [(1S)-2-({(1S)-2-[(3S,8aR)-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-phenylethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate

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Chemical Name:tert-butyl [(1S)-2-({(1S)-2-[(3S,8aR)-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-phenylethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate
CAS No.:1266229-74-6
Molecular Formula:C₃₄H₄₅N₅O₆
Molecular Weight:619.761
Hs Code.:

tert-butyl [(1S)-2-({(1S)-2-[(3S,8aR)-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-phenylethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate

Synonyms:tert-butyl [(1S)-2-({(1S)-2-[(3S,8aR)-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-phenylethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate

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Chemical Property of tert-butyl [(1S)-2-({(1S)-2-[(3S,8aR)-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-phenylethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate

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Technology Process of tert-butyl [(1S)-2-({(1S)-2-[(3S,8aR)-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-phenylethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate

There total 20 articles about tert-butyl [(1S)-2-({(1S)-2-[(3S,8aR)-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-phenylethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1266229-75-7
(3S,8aR)-2-[(2S)-2-amino-2-phenylacetyl]-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]octahydropyrrolo[1,2-a]pyrazine-3-carboxamide

: 16948-16-6
N-(tert-butoxycarbonyl)-N-methyl-L-alanine

: 1266229-74-6
tert-butyl [(1S)-2-({(1S)-2-[(3S,8aR)-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-phenylethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1266229-01-9
2-tert-butyl 3-methyl (3S,8aR)-hexahydropyrrolo[1,2-a]-pyrazine-2,3(1H)-dicarboxylate

: 1266229-74-6
tert-butyl [(1S)-2-({(1S)-2-[(3S,8aR)-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-phenylethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 50 °C

2: benzotriazol-1-ol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 20 °C

3: hydrogenchloride / ethyl acetate / 1 h / 20 °C

4: HATU; dmap / N,N-dimethyl-formamide / 18 h / 0 - 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 2280.15 Torr

6: HATU; dmap / N,N-dimethyl-formamide / 18 h / 0 - 20 °C

With hydrogenchloride; dmap; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm301674z

Reference yield:

: methyl (3S,8aR)-octahydropyrrolo[1,2-a]pyrazine-3-carboxylate dihydrochloride

: 1266229-74-6
tert-butyl [(1S)-2-({(1S)-2-[(3S,8aR)-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-phenylethyl}amino)-1-methyl-2-oxoethyl]methylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 1 h / 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 50 °C

3: benzotriazol-1-ol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 15 h / 20 °C

4: hydrogenchloride / ethyl acetate / 1 h / 20 °C

5: HATU; dmap / N,N-dimethyl-formamide / 18 h / 0 - 20 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / 2280.15 Torr

7: HATU; dmap / N,N-dimethyl-formamide / 18 h / 0 - 20 °C

With hydrogenchloride; dmap; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm301674z