methyl 3-{(E)-2-[2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)phenyl]vinyl}benzoate

Base Information

Chemical Name:methyl 3-{(E)-2-[2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)phenyl]vinyl}benzoate
CAS No.:933799-52-1
Molecular Formula:C₃₃H₂₈ClNO₄
Molecular Weight:538.043
Hs Code.:

Synonyms:methyl 3-{(E)-2-[2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)phenyl]vinyl}benzoate

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Chemical Property of methyl 3-{(E)-2-[2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)phenyl]vinyl}benzoate

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Technology Process of methyl 3-{(E)-2-[2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)phenyl]vinyl}benzoate

There total 7 articles about methyl 3-{(E)-2-[2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)phenyl]vinyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 933799-38-3
2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)benzaldehyde

: 96534-02-0
3-(diethyoxyphosphorylmethyl)benzoic acid methyl ester

: 933799-52-1
methyl 3-{(E)-2-[2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)phenyl]vinyl}benzoate

Guidance literature:: 3-(diethyoxyphosphorylmethyl)benzoic acid methyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)benzaldehyde; In tetrahydrofuran; at 20 ℃; for 5h;
DOI:10.1016/j.bmc.2007.01.046

Reference yield:

: 933799-94-1
5-isopropyl-3-naphthalen-2-ylisoxazole-4-methanol

: 933799-52-1
methyl 3-{(E)-2-[2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)phenyl]vinyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 51 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 1 h / 0 °C

2.1: 64 percent / potassium carbonate / dimethylformamide / 10 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 68 percent / tetrahydrofuran / 5 h / 20 °C

With carbon tetrabromide; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3.2: Horner-Emmons reaction;
DOI:10.1016/j.bmc.2007.01.046

Reference yield:

: 933799-25-8
4-(bromomethyl)-5-isopropyl-3-naphthalen-2-ylisoxazole

: 933799-52-1
methyl 3-{(E)-2-[2-chloro-4-(5-isopropyl-3-naphthalen-2-ylisoxazol-4-ylmethoxy)phenyl]vinyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 64 percent / potassium carbonate / dimethylformamide / 10 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 68 percent / tetrahydrofuran / 5 h / 20 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 2.2: Horner-Emmons reaction;
DOI:10.1016/j.bmc.2007.01.046