ethyl 4-[3-[4-[1-(4-isobutylphenyl)pentyloxy]benzoyl]indol-1-yl]butyrate

Base Information

Chemical Name:ethyl 4-[3-[4-[1-(4-isobutylphenyl)pentyloxy]benzoyl]indol-1-yl]butyrate
CAS No.:148366-62-5
Molecular Formula:C₃₆H₄₃NO₄
Molecular Weight:553.742
Hs Code.:

Synonyms:ethyl 4-[3-[4-[1-(4-isobutylphenyl)pentyloxy]benzoyl]indol-1-yl]butyrate

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Chemical Property of ethyl 4-[3-[4-[1-(4-isobutylphenyl)pentyloxy]benzoyl]indol-1-yl]butyrate

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Technology Process of ethyl 4-[3-[4-[1-(4-isobutylphenyl)pentyloxy]benzoyl]indol-1-yl]butyrate

There total 10 articles about ethyl 4-[3-[4-[1-(4-isobutylphenyl)pentyloxy]benzoyl]indol-1-yl]butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.2%

: 139155-89-8
ethyl 4-{3-(4-Hydroxybenzoyl)indol-1-yl}butanoate

: 148367-08-2
1-bromo-1-(4-isobutylphenyl)pentane

: 148366-62-5
ethyl 4-[3-[4-[1-(4-isobutylphenyl)pentyloxy]benzoyl]indol-1-yl]butyrate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1248/cpb.49.799

Reference yield:

: 120-72-9
indole

: 148366-62-5
ethyl 4-[3-[4-[1-(4-isobutylphenyl)pentyloxy]benzoyl]indol-1-yl]butyrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: AlCl₃ / CH₂Cl₂ / 0.17 h / 20 °C

1.2: 78.4 percent / CH₂Cl₂ / 1 h

2.1: 100 percent / K₂CO₃ / dimethylformamide / 14 h / 20 °C

3.1: 83.5 percent / AlCl₃; ethanethiol / CH₂Cl₂ / 1.5 h / 20 °C

4.1: 61.2 percent / K₂CO₃ / dimethylformamide / 20 °C

With aluminium trichloride; potassium carbonate; ethanethiol; In dichloromethane; N,N-dimethyl-formamide; 1.2: Friedel-Crafts acylation;
DOI:10.1248/cpb.49.799

Reference yield:

: 538-93-2
1-phenyl-2-methylpropane

: 148366-62-5
ethyl 4-[3-[4-[1-(4-isobutylphenyl)pentyloxy]benzoyl]indol-1-yl]butyrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: AlCl₃ / CH₂Cl₂ / 0.5 h / 0 °C

1.2: 99.1 percent / CH₂Cl₂ / 1 h / 0 °C

2.1: 99.1 percent / NaBH₄ / methanol / 1 h / 20 °C

3.1: 45.8 percent / CBr₄; PPh₃ / tetrahydrofuran / 5 h / 20 °C

4.1: 61.2 percent / K₂CO₃ / dimethylformamide / 20 °C

With sodium tetrahydroborate; aluminium trichloride; carbon tetrabromide; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1.2: Friedel-Crafts acylation;
DOI:10.1248/cpb.49.799