Technology Process of N-[(4-hydroxy-2-oxo-8-(3-methylphenyl)-2H-3-chromenyl)carbonyl]glycine
There total 7 articles about N-[(4-hydroxy-2-oxo-8-(3-methylphenyl)-2H-3-chromenyl)carbonyl]glycine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 4h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: acetic acid; bromine / 8 h / 80 °C
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / water; N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere
3.1: 5%-palladium/activated carbon; ammonium formate / water / 2 h / Reflux
4.1: phosphoric acid / 50 °C
5.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 12 h / 0 - 10 °C
5.2: 2 h
6.1: sodium methylate / methanol
6.2: 60 °C
7.1: trifluoroacetic acid / dichloromethane / 4 h
With
tetrakis(triphenylphosphine) palladium(0); phosphoric acid; 5%-palladium/activated carbon; bromine; ammonium formate; sodium methylate; sodium carbonate; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: phosphoric acid / 50 °C
2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 12 h / 0 - 10 °C
2.2: 2 h
3.1: sodium methylate / methanol
3.2: 60 °C
4.1: trifluoroacetic acid / dichloromethane / 4 h
With
phosphoric acid; sodium methylate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane;
