9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,8,9,9a-tetrahydro-2H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,3,5-tricarboxylic acid 3-(4,5-dimethoxy-2-nitro-benzyl) ester 1,5-dimethyl ester

Base Information

Chemical Name:9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,8,9,9a-tetrahydro-2H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,3,5-tricarboxylic acid 3-(4,5-dimethoxy-2-nitro-benzyl) ester 1,5-dimethyl ester
CAS No.:882304-56-5
Molecular Formula:C₃₄H₄₇N₃O₁₃Si
Molecular Weight:733.845
Hs Code.:

9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,8,9,9a-tetrahydro-2<i>H</i>-1,3-diaza-benzo[<i>a</i>]cyclopropa[<i>e</i>]cyclooctene-1,3,5-tricarboxylic acid 3-(4,5-dimethoxy-2-nitro-benzyl) ester 1,5-dimethyl ester

Synonyms:9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,8,9,9a-tetrahydro-2H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,3,5-tricarboxylic acid 3-(4,5-dimethoxy-2-nitro-benzyl) ester 1,5-dimethyl ester

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Chemical Property of 9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,8,9,9a-tetrahydro-2H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,3,5-tricarboxylic acid 3-(4,5-dimethoxy-2-nitro-benzyl) ester 1,5-dimethyl ester

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Technology Process of 9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,8,9,9a-tetrahydro-2H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,3,5-tricarboxylic acid 3-(4,5-dimethoxy-2-nitro-benzyl) ester 1,5-dimethyl ester

There total 9 articles about 9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,8,9,9a-tetrahydro-2H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,3,5-tricarboxylic acid 3-(4,5-dimethoxy-2-nitro-benzyl) ester 1,5-dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 42855-00-5
nitroveratryloxycarbonyl chloride

: 477223-17-9
9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,2,3,8,9,9a-hexahydro-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,5-dicarboxylic acid dimethyl ester

: 882304-56-5
9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,8,9,9a-tetrahydro-2H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,3,5-tricarboxylic acid 3-(4,5-dimethoxy-2-nitro-benzyl) ester 1,5-dimethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine;
DOI:10.1021/ol0266774

Reference yield:

: 125229-14-3
methyl 3-methoxymethyloxy-4-methyl-5-nitrobenzene

: 882304-56-5
9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,8,9,9a-tetrahydro-2H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,3,5-tricarboxylic acid 3-(4,5-dimethoxy-2-nitro-benzyl) ester 1,5-dimethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / NaOMe

2: imidazole / CH₂Cl₂

3: DDQ / CH₂Cl₂

4: H₂ / Pd/C

5: MgSO₄; 4 Angstroem molecular sieves / CH₂Cl₂

6: NaCNBH₃; AcOH

7: 75 percent / DIPEA

With 1H-imidazole; 4 A molecular sieve; hydrogen; sodium methylate; sodium cyanoborohydride; magnesium sulfate; acetic acid; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In dichloromethane; 4: Dess-Martin oxidation;
DOI:10.1021/ol0266774

Reference yield:

: 192061-03-3
(2S-cis)-methyl ester 2-formyl-3-[(4-methoxyphenyl)methoxymethyl]-1-aziridinecarboxylic acid

: 882304-56-5
9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,8,9,9a-tetrahydro-2H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,3,5-tricarboxylic acid 3-(4,5-dimethoxy-2-nitro-benzyl) ester 1,5-dimethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / NaOMe

2: imidazole / CH₂Cl₂

3: DDQ / CH₂Cl₂

4: H₂ / Pd/C

5: MgSO₄; 4 Angstroem molecular sieves / CH₂Cl₂

6: NaCNBH₃; AcOH

7: 75 percent / DIPEA

With 1H-imidazole; 4 A molecular sieve; hydrogen; sodium methylate; sodium cyanoborohydride; magnesium sulfate; acetic acid; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In dichloromethane; 4: Dess-Martin oxidation;
DOI:10.1021/ol0266774