(2S,2'S)-tert-butyl 2,2'-(4,4'-(4,4'-(3-(4-metoxyphenyl)cyclopropane-1,2-diyl)bis(4,1-phenylene))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,2'S)-tert-butyl 2,2'-(4,4'-(4,4'-(3-(4-metoxyphenyl)cyclopropane-1,2-diyl)bis(4,1-phenylene))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate
CAS No.:1382649-97-9
Molecular Formula:C₄₆H₅₄N₆O₅
Molecular Weight:770.972
Hs Code.:

Synonyms:(2S,2'S)-tert-butyl 2,2'-(4,4'-(4,4'-(3-(4-metoxyphenyl)cyclopropane-1,2-diyl)bis(4,1-phenylene))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate

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Chemical Property of (2S,2'S)-tert-butyl 2,2'-(4,4'-(4,4'-(3-(4-metoxyphenyl)cyclopropane-1,2-diyl)bis(4,1-phenylene))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate

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Technology Process of (2S,2'S)-tert-butyl 2,2'-(4,4'-(4,4'-(3-(4-metoxyphenyl)cyclopropane-1,2-diyl)bis(4,1-phenylene))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate

There total 5 articles about (2S,2'S)-tert-butyl 2,2'-(4,4'-(4,4'-(3-(4-metoxyphenyl)cyclopropane-1,2-diyl)bis(4,1-phenylene))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1007882-59-8
(S)-2-(4-bromo-1H-imidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1382249-95-7
2,2'-(4,4'-(3-(4-methoxyphenyl)cyclopropane-1,2-diyl)bis(4,1-phenylene))bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

: 1382649-97-9
(2S,2'S)-tert-butyl 2,2'-(4,4'-(4,4'-(3-(4-metoxyphenyl)cyclopropane-1,2-diyl)bis(4,1-phenylene))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; water; toluene; at 85 ℃; for 18h;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1382649-97-9
(2S,2'S)-tert-butyl 2,2'-(4,4'-(4,4'-(3-(4-metoxyphenyl)cyclopropane-1,2-diyl)bis(4,1-phenylene))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.83 h / -78 °C / Inert atmosphere

1.2: 0.5 h / Cooling with ice; Inert atmosphere

2.1: ammonium hydroxide / methanol

2.2: 20 °C

3.1: N-Bromosuccinimide / dichloromethane / 2 h / 0 °C

4.1: sodium sulfite / 1,4-dioxane; water / 16 h / Reflux

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol; water / 18 h / 85 °C

With ammonium hydroxide; N-Bromosuccinimide; oxalyl dichloride; sodium carbonate; dimethyl sulfoxide; sodium sulfite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene;

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 1382649-97-9
(2S,2'S)-tert-butyl 2,2'-(4,4'-(4,4'-(3-(4-metoxyphenyl)cyclopropane-1,2-diyl)bis(4,1-phenylene))bis(1H-imidazole-4,2-diyl))dipyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium hydroxide / methanol

1.2: 20 °C

2.1: N-Bromosuccinimide / dichloromethane / 2 h / 0 °C

3.1: sodium sulfite / 1,4-dioxane; water / 16 h / Reflux

4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene; ethanol; water / 18 h / 85 °C

With ammonium hydroxide; N-Bromosuccinimide; sodium carbonate; sodium sulfite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene;