benzyl (R)-(+)-benzyl-2-benzamido-3-bromopropanoate

Base Information

• Chemical Name: benzyl (R)-(+)-benzyl-2-benzamido-3-bromopropanoate
• CAS No.: 609366-84-9
• Molecular Formula: C₁₇H₁₆BrNO₃
• Molecular Weight: 362.223
• Mol file: 609366-84-9.mol

Synonyms:benzyl (R)-(+)-benzyl-2-benzamido-3-bromopropanoate

Chemical Property of benzyl (R)-(+)-benzyl-2-benzamido-3-bromopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl (R)-(+)-benzyl-2-benzamido-3-bromopropanoate

There total 3 articles about benzyl (R)-(+)-benzyl-2-benzamido-3-bromopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-benzyl 2-phenyl-4,5-dihydrooxazole-4-carboxylate (609366-75-8) → benzyl (R)-(+)-benzyl-2-benzamido-3-bromopropanoate (609366-84-9)

Guidance literature:

With trimethylsilyl bromide; In chloroform; at 20 ℃; for 48h;

DOI:10.1016/S0957-4166(03)00484-1

Reference yield:

ethyl benzimidate hydrochloride (5333-86-8) → benzyl (R)-(+)-benzyl-2-benzamido-3-bromopropanoate (609366-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N / CHCl₃ / 20 °C

1.2: 96 percent / CHCl₃ / 24 h / Heating

2.1: 99 percent / Me₃SiBr / CHCl₃ / 48 h / 20 °C

With trimethylsilyl bromide; triethylamine; In chloroform;

DOI:10.1016/S0957-4166(03)00484-1

Reference yield:

L-serine benzyl ester hydrochloride (60022-62-0,879278-55-4,151651-44-4) → benzyl (R)-(+)-benzyl-2-benzamido-3-bromopropanoate (609366-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N / CHCl₃ / 20 °C

1.2: 96 percent / CHCl₃ / 24 h / Heating

2.1: 99 percent / Me₃SiBr / CHCl₃ / 48 h / 20 °C

With trimethylsilyl bromide; triethylamine; In chloroform;

DOI:10.1016/S0957-4166(03)00484-1

upstream raw materials:

(S)-benzyl 2-phenyl-4,5-dihydrooxazole-4-carboxylate

ethyl benzimidate hydrochloride

L-serine benzyl ester hydrochloride

Downstream raw materials:

L-N_α-benzoyl-4-[(di-tert-butyl)phosphonomethyl]phenylalanine