5,6-di-O-isopropylidene-2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone

Base Information

• Chemical Name: 5,6-di-O-isopropylidene-2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone
• CAS No.: 502696-53-9
• Molecular Formula: C₁₇H₁₇F₃O₇
• Molecular Weight: 390.313
• Mol file: 502696-53-9.mol

Synonyms:5,6-di-O-isopropylidene-2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone

Chemical Property of 5,6-di-O-isopropylidene-2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6-di-O-isopropylidene-2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone

There total 1 articles about 5,6-di-O-isopropylidene-2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

5,6-O-isopropylidene-D-galactonic acid γ-lactone (56710-46-4,67321-94-2,69602-93-3,94697-68-4,100227-29-0,102355-63-5,121357-95-7) + 3-(Trifluoromethyl)benzoyl chloride (2251-65-2) → 5,6-di-O-isopropylidene-2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone (502696-53-9)

Guidance literature:

With pyridine; In dichloromethane; at -15 ℃; for 4h;

DOI:10.1016/S0008-6215(02)00118-0

Reference yield: 90.0%

5,6-di-O-isopropylidene-2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone (502696-53-9) → 2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone (502696-52-8)

Guidance literature:

With water; acetic acid; at 60 ℃; for 1.5h;

DOI:10.1016/S0008-6215(02)00118-0

Reference yield:

5,6-di-O-isopropylidene-2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone (502696-53-9) → methyl 3,5,6-tri-O-benzoyl-2-deoxy-D-lyxo-hexofuranoside

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / AcOH; water / 1.5 h / 60 °C

2: 93 percent / pyridine / 3 h / 0 °C

3: Mg(ClO₄)2; methylcarbazole / H₂O; propan-2-ol / 3 h / 25 °C / Photolysis

4: 95 percent / bis(3-methyl-2-butyl)borane / tetrahydrofuran / 16 h / 20 °C

5: 90 percent / BF₃ / 3 h / 20 °C

With pyridine; magnesium(II) perchlorate; boron trifluoride; water; bis-(1,2-dimethylpropyl)borane; acetic acid; 1-methyl-9H-carbazole; In tetrahydrofuran; water; isopropyl alcohol;

DOI:10.1016/S0008-6215(02)00118-0

upstream raw materials:

5,6-O-isopropylidene-D-galactonic acid γ-lactone

3-(Trifluoromethyl)benzoyl chloride

Downstream raw materials:

2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone

3,5,6-tri-O-benzoyl-2-deoxy-D-lyxo-hexono-1,4-lactone

1-O-acetyl-3,5,6-tri-O-benzoyl-2-deoxy-D-lyxo-hexofuranose

3,5,6-tri-O-benzoyl-2-O-[3-(trifluoromethyl)benzoyl]-D-galactono-1,4-lactone