11-[2-ethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]oxyundecanoic acid

Base Information

Chemical Name:11-[2-ethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]oxyundecanoic acid
CAS No.:844873-42-3
Molecular Formula:C₂₁H₂₉F₃N₂O₃
Molecular Weight:414.468
Hs Code.:

Synonyms:11-[2-ethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]oxyundecanoic acid

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Chemical Property of 11-[2-ethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]oxyundecanoic acid

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Technology Process of 11-[2-ethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]oxyundecanoic acid

There total 2 articles about 11-[2-ethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]oxyundecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 844873-41-2
11-[2-acetyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]oxyundecanoic acid

: 844873-42-3
11-[2-ethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]oxyundecanoic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; at 20 ℃; for 0.5h;
DOI:10.1248/cpb.52.1385

Reference yield:

: 412301-55-4
11-[3-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-undecanoic acid

: 844873-42-3
11-[2-ethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]oxyundecanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / AlCl₃ / CH₂Cl₂ / 1 h / 20 °C

2: 78 percent / triethylsilane; CF₃CO₂H / 0.5 h / 20 °C

With triethylsilane; aluminium trichloride; trifluoroacetic acid; In dichloromethane; 1: Friedel-Crafts acylation;
DOI:10.1248/cpb.52.1385

Reference yield:

: 844873-42-3
11-[2-ethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)phenyl]oxyundecanoic acid

: 11-[2-Ethyl-5-(3-trifluoromethyl-3H-diazirin-3-yl)-phenoxy]-undecanoic acid [(E)-(1R,2S)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxymethyl)-heptadec-3-enyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide*HCl / acetonitrile; CH₂Cl₂ / 10 h

2: 4.2 mg / Et₃N / CHCl₃; methanol / 24 h / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; chloroform; acetonitrile;
DOI:10.1248/cpb.52.1385