Technology Process of (2R,3R)-2,3-diphenylpentane-1,5-diol
There total 6 articles about (2R,3R)-2,3-diphenylpentane-1,5-diol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 1.5h;
DOI:10.1021/ol500873s
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / dichloromethane / 0.33 h / 0 °C
1.2: 24 h / -78 °C
1.3: 24 h / -78 - 25 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C
With
lithium aluminium tetrahydride; pivaloyl chloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol500873s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 72 h / 20 - 25 °C
2.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide; dichloromethane / 4 h / -10 °C
3.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / dichloromethane / 0.33 h / 0 °C
3.2: 24 h / -78 °C
3.3: 24 h / -78 - 25 °C
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 °C
With
lithium aluminium tetrahydride; sulfur trioxide pyridine complex; pivaloyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
2.1: |Parikh-Doering Oxidation;
DOI:10.1021/ol500873s
