2-(4-methylphenyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole

Base Information

• Chemical Name: 2-(4-methylphenyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole
• CAS No.: 1391927-92-6
• Molecular Formula: C₁₇H₁₂N₄O₂S
• Molecular Weight: 336.374
• Mol file: 1391927-92-6.mol

Synonyms:2-(4-methylphenyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole

Chemical Property of 2-(4-methylphenyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methylphenyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole

There total 2 articles about 2-(4-methylphenyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole (1094338-02-9) + 4-methylphenylboronic acid (5720-05-8) → 2-(4-methylphenyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole (1391927-92-6)

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 150 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

DOI:10.1055/s-0035-1561317

Reference yield:

4-Nitrophenacyl bromide (99-81-0) → 2-(4-methylphenyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole (1391927-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 12 h / Reflux

2: palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol;

DOI:10.1002/ejoc.201200237

Reference yield: 91.0%

bromobenzene (108-86-1,52753-63-6) + 2-(4-methylphenyl)-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole (1391927-92-6) → 2-(4-methylphenyl)-5-phenyl-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 150 ℃; for 1h; Reagent/catalyst; Solvent; Catalytic behavior; Microwave irradiation; Inert atmosphere;

DOI:10.1055/s-0035-1561317

upstream raw materials:

2-bromo-6-(4-nitrophenyl)imidazo[2,1-b][1,3,4]thiadiazole

4-methylphenylboronic acid

4-Nitrophenacyl bromide