C₂₈H₃₇ClFN₅O₂

Base Information

Chemical Name:C₂₈H₃₇ClFN₅O₂
CAS No.:1263197-21-2
Molecular Formula:C₂₈H₃₇ClFN₅O₂
Molecular Weight:530.085
Hs Code.:

C<sub>28</sub>H<sub>37</sub>ClFN<sub>5</sub>O<sub>2</sub>

Synonyms:C₂₈H₃₇ClFN₅O₂

Suppliers and Price of C₂₈H₃₇ClFN₅O₂

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of C₂₈H₃₇ClFN₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of C₂₈H₃₇ClFN₅O₂

There total 16 articles about C₂₈H₃₇ClFN₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263198-31-7
tert-butyl (3R,5S)-3-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-5-{[(1R)-1-(5-fluoro-2-pyridyl)-3-methylbutyl]carbamoyl}piperidine-1-carboxylate

: 1263197-21-2
C₂₈H₃₇ClFN₅O₂

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1016/j.bmc.2013.06.057

Reference yield:

: 534572-20-8
(3S,5R)-1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)piperidine-5-carboxylic acid

: 1263197-21-2
C₂₈H₃₇ClFN₅O₂

Guidance literature:: Multi-step reaction with 12 steps

1.1: triethylamine; diphenylphosphoranyl azide / toluene / 1.5 h / 90 °C

1.2: 3.5 h / 90 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 20 °C

3.1: N,N-dimethyl-formamide; water / 24 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

5.1: sodium hydrogencarbonate / water; 1,4-dioxane / 1.5 h / 0 °C

6.1: acetic acid / toluene / 4 h / 130 °C / Dean-Stark

6.2: 16 h / 20 °C / Dean-Stark

7.1: triethylamine / dichloromethane / 6.25 h / 20 - 40 °C / Cooling with ice

8.1: caesium carbonate; thiophenol / acetonitrile / 2.5 h / 20 °C

9.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h / 20 °C

10.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / Cooling with ice

11.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C / Cooling with ice

12.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; diphenylphosphoranyl azide; hydrogen; sodium hydrogencarbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.06.057

Reference yield:

: 1448902-04-2
1-tert-butyl 3-methyl (3S,5R)-5-(benzyloxycarbonylamino)piperidine-1,3-dicarboxylate

: 1263197-21-2
C₂₈H₃₇ClFN₅O₂

Guidance literature:: Multi-step reaction with 11 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 20 °C

2.1: N,N-dimethyl-formamide; water / 24 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

4.1: sodium hydrogencarbonate / water; 1,4-dioxane / 1.5 h / 0 °C

5.1: acetic acid / toluene / 4 h / 130 °C / Dean-Stark

5.2: 16 h / 20 °C / Dean-Stark

6.1: triethylamine / dichloromethane / 6.25 h / 20 - 40 °C / Cooling with ice

7.1: caesium carbonate; thiophenol / acetonitrile / 2.5 h / 20 °C

8.1: sodium hydrogencarbonate / water; ethyl acetate / 0.5 h / 20 °C

9.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / Cooling with ice

10.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C / Cooling with ice

11.1: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; thiophenol; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2013.06.057