URSODEOXYCHOLIC-2,2,4,4-D4 ACID

Base Information

• Chemical Name: URSODEOXYCHOLIC-2,2,4,4-D4 ACID
• CAS No.: 347841-46-7
• Molecular Formula: C₂₄H₄₀O₄
• Molecular Weight: 397.539
• Mol file: 347841-46-7.mol

Synonyms:URSODEOXYCHOLIC-2,2,4,4-D4 ACID

Chemical Property of URSODEOXYCHOLIC-2,2,4,4-D4 ACID

Chemical Property:

• PSA: 77.76000
• LogP: 4.47790
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly),

Purity/Quality:

99% ^*data from raw suppliers

Ursodeoxycholic-2,2,4,4-d4acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Ursodeoxycholic acid-d4 (UDCA-d4) is intended for use as an internal standard for the quantification of UDCA (Item No. 15121) by GC- or LC-MS. UDCA is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; ). UDCA is also a metabolite of lithocholic acid (LCA; ) in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.
• Uses: Ursodeoxycholic Acid-d4 is a deuterated form of Ursodeoxcholic Acid (U850000), which is used as an anticholelithogenic. Ursodeoxcholic Acid is an epimer with Chenodiol with respect to the hydroxyl group at C7. Ursodeoxycholic Acid-d4 was used as an internal standard for rapid quantification of bile acids by liquid chromatography-tandem mass spectrometry.

Technology Process of URSODEOXYCHOLIC-2,2,4,4-D4 ACID

There total 1 articles about URSODEOXYCHOLIC-2,2,4,4-D4 ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2α,2β,3β,4α,4β-Pentadeuterochenodesoxycholsaeure (52840-12-7,93701-18-9,347841-46-7)

Guidance literature:

entspr. Methylester, methanol. NaOH (Deuterierung d.Pos. zu 85,6percent);

DOI:10.1002/jlcr.2590090412

Refernces