((2S,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)methanol

Base Information

• Chemical Name: ((2S,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)methanol
• CAS No.: 1283146-14-4
• Molecular Formula: C₁₁H₁₃BrFNO
• Molecular Weight: 274.133
• Mol file: 1283146-14-4.mol

Synonyms:((2S,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)methanol

Chemical Property of ((2S,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2S,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)methanol

There total 5 articles about ((2S,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,4-bromoiodobenzene (589-87-7) + ((2S,4S)-4-fluoropyrrolidin-2-yl)methanol hydrochloride → ((2S,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)methanol (1283146-14-4)

Guidance literature:

With copper(l) iodide; sodium hydroxide; In isopropyl alcohol; at 90 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.jmedchem.6b01559

Reference yield: 78.0%

→ ((2S,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)methanol (1283146-14-4)

Guidance literature:

Reference yield:

tert-butyl (2S,4S)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate (317356-27-7,1138324-48-7) → ((2S,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)methanol (1283146-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; copper(l) iodide; sodium hydroxide; In 1,4-dioxane; isopropyl alcohol;

DOI:10.1021/acs.jmedchem.6b01559

upstream raw materials:

1,4-bromoiodobenzene

tert-butyl (2S,4S)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate

(2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid

Downstream raw materials:

2-((2R,4S)-1-(4-bromophenyl)-4-fluoropyrrolidin-2-yl)acetonitrile

2-((2R,4S)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt