tert-butyl 4-(2-methoxy-1-{[methyl(phenyl)amino]sulfonyl}-2-oxoethyl)benzoate

Base Information

• Chemical Name: tert-butyl 4-(2-methoxy-1-{[methyl(phenyl)amino]sulfonyl}-2-oxoethyl)benzoate
• CAS No.: 957070-16-5
• Molecular Formula: C₂₁H₂₅NO₆S
• Molecular Weight: 419.499
• Mol file: 957070-16-5.mol

Synonyms:tert-butyl 4-(2-methoxy-1-{[methyl(phenyl)amino]sulfonyl}-2-oxoethyl)benzoate

Chemical Property of tert-butyl 4-(2-methoxy-1-{[methyl(phenyl)amino]sulfonyl}-2-oxoethyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(2-methoxy-1-{[methyl(phenyl)amino]sulfonyl}-2-oxoethyl)benzoate

There total 1 articles about tert-butyl 4-(2-methoxy-1-{[methyl(phenyl)amino]sulfonyl}-2-oxoethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

tert-butyl-4-bromobenzoate (59247-47-1) + methyl {[methyl(phenyl)amino]sulfonyl}acetate (117765-67-0) → tert-butyl 4-(2-methoxy-1-{[methyl(phenyl)amino]sulfonyl}-2-oxoethyl)benzoate (957070-16-5)

Guidance literature:

methyl {[methyl(phenyl)amino]sulfonyl}acetate; With sodium t-butanolate; In 1,4-dioxane; at 20 ℃; for 0.25h;

tert-butyl-4-bromobenzoate; With tri tert-butylphosphoniumtetrafluoroborate; palladium diacetate; In 1,4-dioxane; at 90 ℃; for 0.25h; Further stages.;

DOI:10.1021/jo701431j

Reference yield: 79.0%

tert-butyl 4-(2-methoxy-1-{[methyl(phenyl)amino]sulfonyl}-2-oxoethyl)benzoate (957070-16-5) + aniline (62-53-3) → tert-butyl 4-[1-(anilinosulfonyl)-2-methoxy-2-oxoethyl]benzoate

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 2h;

DOI:10.1021/jo701431j

Reference yield: 65.0%

tert-butyl 4-(2-methoxy-1-{[methyl(phenyl)amino]sulfonyl}-2-oxoethyl)benzoate (957070-16-5) + methoxycarbonylmethylamine (616-34-2) → tert-butyl 4-(2-methoxy-1-{[(2-methoxy-2-oxoethyl)amino]sulfonyl}-2-oxoethyl)benzoate

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 1h;

DOI:10.1021/jo701431j

upstream raw materials:

tert-butyl-4-bromobenzoate

methyl {[methyl(phenyl)amino]sulfonyl}acetate