(+)-Desmethyl-Rolipram

Base Information

• Chemical Name: (+)-Desmethyl-Rolipram
• CAS No.: 347148-59-8
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 261.321
• Mol file: 347148-59-8.mol

Synonyms:(+)-Desmethyl-Rolipram;2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-hydroxyphenyl]-, (4R)-;R-Desmethyl-Rolipram

Chemical Property of (+)-Desmethyl-Rolipram

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-Desmethyl-Rolipram

There total 4 articles about (+)-Desmethyl-Rolipram which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

Rolipram (61413-54-5) → 4-[3,4-dihydroxyphenyl]-2-pyrrolidone + 4-(3-hydroxy-4-methoxyphenyl)-pyrrolidin-2-one (57724-60-4) + R/S-desmethylrolipram (150519-28-1,347148-59-8,347148-60-1)

Guidance literature:

With trimethylsilyl iodide; In chloroform; at 20 ℃; for 64h;

DOI:10.1002/jlcr.465

Reference yield:

Rolipram (61413-54-5) → R-desmethylrolipram (150519-28-1,347148-59-8,347148-60-1) + S-desmethylrolipram (150519-28-1,347148-59-8,347148-60-1)

Guidance literature:

With trimethylsilyl iodide; In chloroform; at 20 ℃; for 64h;

DOI:10.1002/jlcr.465

Reference yield:

Rolipram (61413-54-5) → R-desmethylrolipram (150519-28-1,347148-59-8,347148-60-1) + S-desmethylrolipram (150519-28-1,347148-59-8,347148-60-1)

Guidance literature:

With trimethylsilyl iodide; In chloroform; at 20 ℃; for 64h;

DOI:10.1002/jlcr.465

upstream raw materials:

Rolipram

Downstream raw materials:

(R)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one