6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-6,7-dihydro-1H-purine-2-carbonitrile

Base Information

Chemical Name:6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-6,7-dihydro-1H-purine-2-carbonitrile
CAS No.:1243708-11-3
Molecular Formula:C₂₀H₁₆F₃N₇O
Molecular Weight:427.389
Hs Code.:

Synonyms:6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-6,7-dihydro-1H-purine-2-carbonitrile

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Chemical Property of 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-6,7-dihydro-1H-purine-2-carbonitrile

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Technology Process of 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-6,7-dihydro-1H-purine-2-carbonitrile

There total 5 articles about 6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-6,7-dihydro-1H-purine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 773837-37-9
sodium cyanide

: 1243706-25-3
2-chloro-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-1,7-dihydropurin-6-one

: 1243708-11-3
6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-6,7-dihydro-1H-purine-2-carbonitrile

Guidance literature:: With sodium iodide; In N,N-dimethyl-formamide; at 65 - 75 ℃; for 48h;

Reference yield:

: 142665-13-2
5,6-diamino-3-propyluracil

: 1243708-11-3
6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-6,7-dihydro-1H-purine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 6 h / 0 - 25 °C

2: phosphorus pentoxide / N,N-dimethyl-formamide / 0.5 h / 100 °C

3: trichlorophosphate; ammonium chloride / 72 h / 120 - 125 °C

4: sodium iodide / N,N-dimethyl-formamide / 48 h / 65 - 75 °C

With phosphorus pentoxide; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; trichlorophosphate; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1-propyl-8-(1-{[3-(trifluoromethyl)phenyl]-methyl}pyrazol-4-yl)-1,3,7-trihydropurine-2,6-dione

: 1243708-11-3
6-oxo-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-6,7-dihydro-1H-purine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate; ammonium chloride / 72 h / 120 - 125 °C

2: sodium iodide / N,N-dimethyl-formamide / 48 h / 65 - 75 °C

With ammonium chloride; sodium iodide; trichlorophosphate; In N,N-dimethyl-formamide;