2,2,2-trfluoroethyl 3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamate

Base Information

Chemical Name:2,2,2-trfluoroethyl 3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamate
CAS No.:1187212-92-5
Molecular Formula:C₂₅H₂₂F₄N₄O₄S
Molecular Weight:550.534
Hs Code.:

Synonyms:2,2,2-trfluoroethyl 3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamate

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Chemical Property of 2,2,2-trfluoroethyl 3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamate

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Technology Process of 2,2,2-trfluoroethyl 3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamate

There total 6 articles about 2,2,2-trfluoroethyl 3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.3%

: 1187214-21-6
4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl 2,2,2-trifluoroethyl methylcarbamate

: 1187212-92-5
2,2,2-trfluoroethyl 3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamate

Guidance literature:: 4-(2-(5-((tert-butoxycarbonyl(2-methoxyethyl)amino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl 2,2,2-trifluoroethyl methylcarbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1187212-92-5
2,2,2-trfluoroethyl 3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

2.1: tetrahydrofuran / 16 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1 h / -78 - 20 °C

3.3: 1 h / Reflux

4.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h

4.2: 0.75 h / 100 °C

5.1: tetrahydrofuran / 2 h

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With n-butyllithium; potassium tert-butylate; sodium tris(acetoxy)borohydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1123837-99-9
N-((6-bromopyridin-3-yl)methyl)-2-methoxyethan-1-amine

: 1187212-92-5
2,2,2-trfluoroethyl 3-fluoro-4-(2-(5-((2-methoxyethylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 16 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

2.2: 1 h / -78 - 20 °C

2.3: 1 h / Reflux

3.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h

3.2: 0.75 h / 100 °C

4.1: tetrahydrofuran / 2 h

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With n-butyllithium; potassium tert-butylate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;