2-[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ⁵-phospholan-1-ylidene]-3-oxosuccinic acid diethyl ester

Base Information

• Chemical Name: 2-[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ⁵-phospholan-1-ylidene]-3-oxosuccinic acid diethyl ester
• CAS No.: 802333-80-8
• Molecular Formula: C₂₈H₄₃O₅P
• Molecular Weight: 490.62

Synonyms:2-[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ⁵-phospholan-1-ylidene]-3-oxosuccinic acid diethyl ester

Chemical Property of 2-[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ⁵-phospholan-1-ylidene]-3-oxosuccinic acid diethyl ester

Chemical Property:

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Technology Process of 2-[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ⁵-phospholan-1-ylidene]-3-oxosuccinic acid diethyl ester

There total 3 articles about 2-[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ⁵-phospholan-1-ylidene]-3-oxosuccinic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

acetylenedicarboxylic acid diethyl ester (762-21-0) + 3-methyl-1-(2,4,6-triisopropylphenyl-)2,3,4,5-tetrahydro-1H-phosphole 1-oxide (292612-57-8) → 2-[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ5-phospholan-1-ylidene]-3-oxosuccinic acid diethyl ester (802333-80-8)

Guidance literature:

at 150 ℃; for 168h;

Reference yield:

2-[3-methyl-1-(2,4,6-triisopropyl-phenyl)-1λ5-phospholan-1-ylidene]-3-oxo-succinic acid dimethyl ester (412044-99-6) → 2-[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ5-phospholan-1-ylidene]-3-oxosuccinic acid diethyl ester (802333-80-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / hydroxylamine hydrochloride / methanol / 72 h / Heating

2: 168 h / 120 °C

3: 83 percent / 168 h / 150 °C

With hydroxylamine hydrochloride; In methanol; 2: Wittig reaction;

Reference yield:

[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ5-phospholan-1-ylidene]-acetic acid methyl ester (802333-81-9) → 2-[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ5-phospholan-1-ylidene]-3-oxosuccinic acid diethyl ester (802333-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 168 h / 120 °C

2: 83 percent / 168 h / 150 °C

1: Wittig reaction;

upstream raw materials:

acetylenedicarboxylic acid diethyl ester

3-methyl-1-(2,4,6-triisopropylphenyl-)2,3,4,5-tetrahydro-1H-phosphole 1-oxide

2-[3-methyl-1-(2,4,6-triisopropyl-phenyl)-1λ⁵-phospholan-1-ylidene]-3-oxo-succinic acid dimethyl ester

[3-methyl-1-(2,4,6-triisopropylphenyl)-1λ⁵-phospholan-1-ylidene]-acetic acid methyl ester

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