N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-2-(4-(methylamino)piperidine-1-carbonyl)phenyl)acetamide

Base Information

Chemical Name:N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-2-(4-(methylamino)piperidine-1-carbonyl)phenyl)acetamide
CAS No.:1464152-45-1
Molecular Formula:C₂₉H₂₈N₆O₂
Molecular Weight:492.58
Hs Code.:

Synonyms:N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-2-(4-(methylamino)piperidine-1-carbonyl)phenyl)acetamide

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Chemical Property of N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-2-(4-(methylamino)piperidine-1-carbonyl)phenyl)acetamide

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Technology Process of N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-2-(4-(methylamino)piperidine-1-carbonyl)phenyl)acetamide

There total 9 articles about N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-2-(4-(methylamino)piperidine-1-carbonyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1464158-00-6
tert-butyl 1-(2-acetamido-4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)benzoyl)piperidin-4-yl(methyl)carbamate

: 1464152-45-1
N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-2-(4-(methylamino)piperidine-1-carbonyl)phenyl)acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 76561-16-5
7-bromo-1,2-dihydro-3,1-4H-benzoxazine-2,4-dione

: 1464152-45-1
N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-2-(4-(methylamino)piperidine-1-carbonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / N,N-dimethyl-formamide / 16 h / 20 °C

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,4-dioxane / 16 h / 90 °C

4: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 20776-50-5
2-amino-4-bromobenzoic acid

: 1464152-45-1
N-(5-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)-2-(4-(methylamino)piperidine-1-carbonyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 16 h / 0 - 110 °C

2: dmap / N,N-dimethyl-formamide / 16 h / 20 °C

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / water; 1,4-dioxane / 16 h / 90 °C

5: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With dmap; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;