AKOS B030638

Base Information

• Chemical Name: AKOS B030638
• CAS No.: 70442-56-7
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• Mol file: 70442-56-7.mol

Synonyms:4-(2,3-dimethylphenoxy)butanoic acid

Chemical Property of AKOS B030638

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

4-(2,3-Dimethyl-phenoxy)-butyric acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AKOS B030638

There total 2 articles about AKOS B030638 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(2,3-dimethylphenoxy)butyric acid ethyl ester (56359-23-0) → 4-(2,3-dimethylphenoxy)butanoic acid (70442-56-7)

Guidance literature:

4-(2,3-dimethylphenoxy)butyric acid ethyl ester; With lithium hydroxide; In 1,4-dioxane; at 60 ℃; for 4h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; pH=2 - 3;

Reference yield:

2,3-Dimethylphenol (526-75-0) → 4-(2,3-dimethylphenoxy)butanoic acid (70442-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / tetrahydrofuran / 20 h / 60 °C

2.1: lithium hydroxide / 1,4-dioxane / 4 h / 60 °C

2.2: 20 °C / pH 2 - 3

With tetra-(n-butyl)ammonium iodide; potassium carbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane;

Reference yield: 74.0%

4-(2,3-dimethylphenoxy)butanoic acid (70442-56-7) + 5-bromo-1,2,3,4-tetrahydroquinoline hydrochloride → 1-(5-bromo-3,4-dihydroquinolin-1(2H)-yl)-4-(2,3-dimethylphenoxy)butan-1-one

Guidance literature:

With propylphosphonic acid; N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 0 - 20 ℃;

upstream raw materials:

4-(2,3-dimethylphenoxy)butyric acid ethyl ester

2,3-Dimethylphenol

Downstream raw materials:

methyl 4-(1-(4-(2,3-dimethylphenoxy)butanoyl)-1,2,3,4-tetrahydroquinolin-5-yl)picolinate

4-(1-(4-(2,3-dimethylphenoxy)butanoyl)-1,2,3,4-tetrahydroquinolin-5-yl)picolinic acid