(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(thiophene-3-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Base Information

Chemical Name:(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(thiophene-3-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline
CAS No.:1438285-43-8
Molecular Formula:C₂₇H₃₀N₂S
Molecular Weight:414.615
Hs Code.:

Synonyms:(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(thiophene-3-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Suppliers and Price of (4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(thiophene-3-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(thiophene-3-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(thiophene-3-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

There total 12 articles about (4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(thiophene-3-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1438285-42-7
C₃₀H₃₈N₂SSi

: 1438285-43-8
(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(thiophene-3-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Guidance literature:: With tetrabutyl ammonium fluoride; In 1,4-dioxane; at 23 ℃; Inert atmosphere; Heating;
DOI:10.1021/jo400695c

Reference yield:

: 1225377-69-4
2-((1S,2R,3R,5R)-3-ethynyl-2-(3-hydroxypropyl)-3-(benzylamino)-5-methylcyclohexyl)acetonitrile

: 1438285-43-8
(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(thiophene-3-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; 1H-imidazole / tetrachloromethane / 15 h / 77 °C / Inert atmosphere

2: dicarbonylcyclopentadienylcobalt / tetrahydrofuran / 140 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / 1,4-dioxane / 23 °C / Inert atmosphere; Heating

With 1H-imidazole; dicarbonylcyclopentadienylcobalt; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane;
DOI:10.1021/jo400695c

Reference yield:

: 1225377-71-8
2-((4aR,5R,7S,8aS)-1-benzyl-8a-ethynyl-7-methyldecahydroquinolin-5-yl)acetonitrile

: 1438285-43-8
(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(thiophene-3-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Guidance literature:: Multi-step reaction with 2 steps

1: dicarbonylcyclopentadienylcobalt / tetrahydrofuran / 140 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / 1,4-dioxane / 23 °C / Inert atmosphere; Heating

With dicarbonylcyclopentadienylcobalt; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo400695c