2-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)acetic acid

Base Information

Chemical Name:2-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)acetic acid
CAS No.:1330676-53-3
Molecular Formula:C₁₉H₁₇F₂N₃O₄
Molecular Weight:389.358
Hs Code.:

Synonyms:2-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)acetic acid

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Chemical Property of 2-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)acetic acid

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Technology Process of 2-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)acetic acid

There total 4 articles about 2-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1330676-45-3
4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-phenyloxazol-5(4H)-one

: 1330676-53-3
2-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)acetic acid

Guidance literature:: 4-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzylidene)-2-phenyloxazol-5(4H)-one; With sodium hydroxide; In water; at 80 - 90 ℃; for 7h;

With dihydrogen peroxide; sodium hydroxide; In water; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2011.06.022

Reference yield:

: 1330676-37-3
4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)benzaldehyde

: 1330676-53-3
2-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate; acetic anhydride / 2 h / 85 °C / Inert atmosphere

2.1: sodium hydroxide / water / 7 h / 80 - 90 °C

2.2: 0 - 20 °C

With sodium acetate; acetic anhydride; sodium hydroxide; In water;
DOI:10.1016/j.bmcl.2011.06.022

Reference yield:

: 86386-76-7,123632-22-4,141113-42-0,150024-48-9
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole

: 1330676-53-3
2-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propoxy)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutylammomium bromide; potassium carbonate / ethyl acetate / 12 h / 80 °C / Inert atmosphere

2.1: sodium acetate; acetic anhydride / 2 h / 85 °C / Inert atmosphere

3.1: sodium hydroxide / water / 7 h / 80 - 90 °C

3.2: 0 - 20 °C

With tetrabutylammomium bromide; sodium acetate; acetic anhydride; potassium carbonate; sodium hydroxide; In water; ethyl acetate;
DOI:10.1016/j.bmcl.2011.06.022