methyl (R)-3-O-(4,4'-dimethoxytrityl)-2-O-propargyl-glycerate

Base Information

• Chemical Name: methyl (R)-3-O-(4,4'-dimethoxytrityl)-2-O-propargyl-glycerate
• CAS No.: 606124-30-5
• Molecular Formula: C₂₈H₂₈O₆
• Molecular Weight: 460.527
• Mol file: 606124-30-5.mol

Synonyms:methyl (R)-3-O-(4,4'-dimethoxytrityl)-2-O-propargyl-glycerate

Chemical Property of methyl (R)-3-O-(4,4'-dimethoxytrityl)-2-O-propargyl-glycerate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (R)-3-O-(4,4'-dimethoxytrityl)-2-O-propargyl-glycerate

There total 2 articles about methyl (R)-3-O-(4,4'-dimethoxytrityl)-2-O-propargyl-glycerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methyl (R)-2-O-allyl-3-O-dimethoxytrityl-glycerate (402856-26-2) → methyl (R)-3-O-(4,4'-dimethoxytrityl)-2-O-propargyl-glycerate (606124-30-5)

Guidance literature:

methyl (R)-2-O-allyl-3-O-dimethoxytrityl-glycerate; With sodium periodate; osmium(VIII) oxide; In diethyl ether; water; for 18h;

With dimethoxy(diazomethyl)phosphonate; potassium carbonate; In tetrahydrofuran; methanol; at 0 - 20 ℃;

DOI:10.1002/ejoc.200300052

Reference yield: 56.0%

→ methyl (R)-3-O-(4,4'-dimethoxytrityl)-2-O-propargyl-glycerate (606124-30-5)

Guidance literature:

With ammonium cerium(IV) nitrate; In acetone; at 0 ℃; for 0.166667h;

DOI:10.1002/ejoc.200300052

Reference yield:

methyl (R)-3-O-(4,4'-dimethoxytrityl)-2-O-propargyl-glycerate (606124-30-5) → methyl 2-O-propargyl-3-O-{[(R)-3,3,3-trifluoro-2-methoxy-2-phenyl]-propionyl}glycerate

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / acetic acid / 4 h / 20 °C

2: 85 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 15 h

With dmap; acetic acid; triethylamine; In dichloromethane; 1: Ohira-Bestmann route / 2: Ohira-Bestmann route;

DOI:10.1002/ejoc.200300052

upstream raw materials:

methyl (R)-2-O-allyl-3-O-dimethoxytrityl-glycerate