N,N-bis(4-methoxybenzyl)-5-(((3S)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Base Information

Chemical Name:N,N-bis(4-methoxybenzyl)-5-(((3S)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine
CAS No.:1450620-17-3
Molecular Formula:C₂₈H₃₂N₄O₄S
Molecular Weight:520.652
Hs Code.:

Synonyms:N,N-bis(4-methoxybenzyl)-5-(((3S)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

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Chemical Property of N,N-bis(4-methoxybenzyl)-5-(((3S)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

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Technology Process of N,N-bis(4-methoxybenzyl)-5-(((3S)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

There total 9 articles about N,N-bis(4-methoxybenzyl)-5-(((3S)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1450620-18-4
(3S)-1-((6-chloro-3-pyridinyl)sulfonyl)-3-(1-propyn-1-yl)piperazine

: 17061-62-0
N,N-bis(p-methoxybenzyl)amine

: 1450620-17-3
N,N-bis(4-methoxybenzyl)-5-(((3S)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 2-methyl-propan-1-ol; at 132 ℃; for 3h; Microwave irradiation;

Reference yield:

: 1361224-50-1
benzyl 3-(propan-1-yn-1-yl)piperazine-1-carboxylate

: 1450620-17-3
N,N-bis(4-methoxybenzyl)-5-(((3S)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; dmap / dichloromethane / 0.5 h / 20 °C

2.1: Chiralpak^? ADH column / ethanol / Resolution of racemate

3.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

4.1: trifluorormethanesulfonic acid; trifluoroacetic acid / 0.05 h / 20 °C

4.2: 0.08 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine / 2-methyl-propan-1-ol / 3 h / 132 °C / Microwave irradiation

With dmap; trifluorormethanesulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; 2-methyl-propan-1-ol;

Reference yield:

: 1450620-14-0
4-benzyl 1-tert-butyl 2-(1-propyn-1-yl)-1,4-piperazinedicarboxylate

: 1450620-17-3
N,N-bis(4-methoxybenzyl)-5-(((3S)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Chiralpak^? ADH column / ethanol / Resolution of racemate

2.1: trifluoroacetic acid / dichloromethane / 0.67 h / 20 °C

3.1: trifluorormethanesulfonic acid; trifluoroacetic acid / 0.05 h / 20 °C

3.2: 0.08 h / 0 °C

4.1: N-ethyl-N,N-diisopropylamine / 2-methyl-propan-1-ol / 3 h / 132 °C / Microwave irradiation

With trifluorormethanesulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; 2-methyl-propan-1-ol;