2-Benzoylamino-propionic acid 4-(benzyloxycarbonylamino-imino-methyl)-phenyl ester

Base Information

• Chemical Name: 2-Benzoylamino-propionic acid 4-(benzyloxycarbonylamino-imino-methyl)-phenyl ester
• CAS No.: 76223-95-5
• Molecular Formula: C₂₅H₂₃N₃O₅
• Molecular Weight: 445.475
• Mol file: 76223-95-5.mol

Synonyms:2-Benzoylamino-propionic acid 4-(benzyloxycarbonylamino-imino-methyl)-phenyl ester

Chemical Property of 2-Benzoylamino-propionic acid 4-(benzyloxycarbonylamino-imino-methyl)-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-Benzoylamino-propionic acid 4-(benzyloxycarbonylamino-imino-methyl)-phenyl ester

There total 3 articles about 2-Benzoylamino-propionic acid 4-(benzyloxycarbonylamino-imino-methyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

N-(benzyloxycarbonyl)-p-amidinophenol (76223-53-5) + N-Benzoylalanine (2198-64-3,1205-02-3,90988-29-7) → 2-Benzoylamino-propionic acid 4-(benzyloxycarbonylamino-imino-methyl)-phenyl ester (76223-95-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In acetonitrile; at 0 - 20 ℃;

Reference yield:

p-amidinophenol hydrochloride (38148-63-9) → 2-Benzoylamino-propionic acid 4-(benzyloxycarbonylamino-imino-methyl)-phenyl ester (76223-95-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / Et₃N / dimethylformamide / 2 h / Ambient temperature

2: 81 percent / 5percent NaOH / ethanol / 1.5 h / Ambient temperature

3: 26 percent / DCC / acetonitrile / 0 - 20 °C

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

N,O-bis(benzyloxycarbonyl)-p-amidinophenol (76223-55-7) → 2-Benzoylamino-propionic acid 4-(benzyloxycarbonylamino-imino-methyl)-phenyl ester (76223-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 5percent NaOH / ethanol / 1.5 h / Ambient temperature

2: 26 percent / DCC / acetonitrile / 0 - 20 °C

With sodium hydroxide; dicyclohexyl-carbodiimide; In ethanol; acetonitrile;

upstream raw materials:

N-(benzyloxycarbonyl)-p-amidinophenol

N-Benzoylalanine

p-amidinophenol hydrochloride

N,O-bis(benzyloxycarbonyl)-p-amidinophenol

Downstream raw materials:

N-benzoyl-DL-alanine p-amidinophenyl ester p-toluenesulfonate