(6S,7S,E)-methyl 6-(benzyloxy)-9-(tert-butyldiphenylsilyloxy)-7-(4-methoxybenzyloxy)non-2-enoate

Base Information

Chemical Name:(6S,7S,E)-methyl 6-(benzyloxy)-9-(tert-butyldiphenylsilyloxy)-7-(4-methoxybenzyloxy)non-2-enoate
CAS No.:1372785-59-5
Molecular Formula:C₄₁H₅₀O₆Si
Molecular Weight:666.93
Hs Code.:

Synonyms:(6S,7S,E)-methyl 6-(benzyloxy)-9-(tert-butyldiphenylsilyloxy)-7-(4-methoxybenzyloxy)non-2-enoate

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Chemical Property of (6S,7S,E)-methyl 6-(benzyloxy)-9-(tert-butyldiphenylsilyloxy)-7-(4-methoxybenzyloxy)non-2-enoate

Chemical Property:

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Technology Process of (6S,7S,E)-methyl 6-(benzyloxy)-9-(tert-butyldiphenylsilyloxy)-7-(4-methoxybenzyloxy)non-2-enoate

There total 11 articles about (6S,7S,E)-methyl 6-(benzyloxy)-9-(tert-butyldiphenylsilyloxy)-7-(4-methoxybenzyloxy)non-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1384898-59-2
C₃₈H₄₆O₅Si

: 21204-67-1,2605-67-6
methyl (triphenylphosphoranylidene)acetate

: 1372785-59-5
(6S,7S,E)-methyl 6-(benzyloxy)-9-(tert-butyldiphenylsilyloxy)-7-(4-methoxybenzyloxy)non-2-enoate

Guidance literature:: In benzene; for 2h; Reflux;
DOI:10.1016/j.tetasy.2012.02.009

Reference yield:

: 1372785-57-3
(3S,4S)-1-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)oct-7-en-4-ol

: 1372785-59-5
(6S,7S,E)-methyl 6-(benzyloxy)-9-(tert-butyldiphenylsilyloxy)-7-(4-methoxybenzyloxy)non-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; paraffin oil / 0.5 h / 0 °C

1.2: 5 h / 20 °C

2.1: ozone / dichloromethane / 0.25 h / -78 °C

2.2: -78 °C

3.1: benzene / 2 h / Reflux

With sodium hydride; ozone; In tetrahydrofuran; dichloromethane; paraffin oil; benzene; 3.1: Wittig reaction;
DOI:10.1016/j.tetasy.2012.02.009

Reference yield:

: 1372785-52-8
(S)-4-((S)-1-(4-methoxybenzyloxy)but-3-enyl)-2,2-dimethyl-1,3-dioxolane

: 1372785-59-5
(6S,7S,E)-methyl 6-(benzyloxy)-9-(tert-butyldiphenylsilyloxy)-7-(4-methoxybenzyloxy)non-2-enoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: ozone / dichloromethane / 0.25 h / -78 °C

1.2: -78 °C

2.1: sodium tetrahydroborate / methanol / 0 - 20 °C

3.1: 1H-imidazole / dichloromethane / 0 - 20 °C

4.1: copper(II) choride dihydrate / acetonitrile / 0 - 20 °C

5.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 0.5 h / 20 °C

6.1: potassium carbonate / methanol / 1 h / 20 °C

7.1: magnesium / diethyl ether

7.2: 2 h / -40 - 20 °C

8.1: sodium hydride / tetrahydrofuran; paraffin oil / 0.5 h / 0 °C

8.2: 5 h / 20 °C

9.1: ozone / dichloromethane / 0.25 h / -78 °C

9.2: -78 °C

10.1: benzene / 2 h / Reflux

With 1H-imidazole; sodium tetrahydroborate; copper(II) choride dihydrate; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; ozone; magnesium; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile; paraffin oil; benzene; 10.1: Wittig reaction;
DOI:10.1016/j.tetasy.2012.02.009