3-cyano-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)benzamide

Base Information

Chemical Name:3-cyano-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)benzamide
CAS No.:1465825-72-2
Molecular Formula:C₂₇H₂₆N₆O₅S
Molecular Weight:546.607
Hs Code.:

Synonyms:3-cyano-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)benzamide

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Chemical Property of 3-cyano-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)benzamide

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Technology Process of 3-cyano-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)benzamide

There total 5 articles about 3-cyano-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₃N₅O₄S

: 1711-11-1
3-cyanobenzoyl chloride

: 1465825-72-2
3-cyano-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2014.01.039

Reference yield:

: 925702-74-5
C₁₀H₁₀FN₃O₅

: 1465825-72-2
3-cyano-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: ammonium formate; palladium 10% on activated carbon / tetrahydrofuran; ethanol

3: acetic acid / tetrahydrofuran; ethanol; 1,4-dioxane / 20 °C

4: triethylamine / dichloromethane / 20 °C

With palladium 10% on activated carbon; ammonium formate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.01.039

Reference yield:

: C₁₄H₂₄N₄O₂

: 1465825-72-2
3-cyano-N-(1-(3-methoxypropyl)-6-morpholino-2-(5-nitrothiophen-2-yl)-1H-benzo[d]imidazol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / tetrahydrofuran; ethanol; 1,4-dioxane / 20 °C

2: triethylamine / dichloromethane / 20 °C

With acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.01.039