(Z)-(2S,8R,9R)-9-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3,6-trimethyl-10-oxo-7-oxa-4-thia-1-aza-bicyclo[6.2.0]dec-5-ene-2,5-dicarboxylic acid 2-benzyl ester 5-(4-nitro-benzyl) ester

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Chemical Name:(Z)-(2S,8R,9R)-9-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3,6-trimethyl-10-oxo-7-oxa-4-thia-1-aza-bicyclo[6.2.0]dec-5-ene-2,5-dicarboxylic acid 2-benzyl ester 5-(4-nitro-benzyl) ester
CAS No.:86255-96-1
Molecular Formula:C₃₄H₂₉N₃O₁₀S
Molecular Weight:671.684
Hs Code.:

(Z)-(2S,8R,9R)-9-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3,6-trimethyl-10-oxo-7-oxa-4-thia-1-aza-bicyclo[6.2.0]dec-5-ene-2,5-dicarboxylic acid 2-benzyl ester 5-(4-nitro-benzyl) ester

Synonyms:(Z)-(2S,8R,9R)-9-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3,6-trimethyl-10-oxo-7-oxa-4-thia-1-aza-bicyclo[6.2.0]dec-5-ene-2,5-dicarboxylic acid 2-benzyl ester 5-(4-nitro-benzyl) ester

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Chemical Property of (Z)-(2S,8R,9R)-9-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3,6-trimethyl-10-oxo-7-oxa-4-thia-1-aza-bicyclo[6.2.0]dec-5-ene-2,5-dicarboxylic acid 2-benzyl ester 5-(4-nitro-benzyl) ester

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Technology Process of (Z)-(2S,8R,9R)-9-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3,6-trimethyl-10-oxo-7-oxa-4-thia-1-aza-bicyclo[6.2.0]dec-5-ene-2,5-dicarboxylic acid 2-benzyl ester 5-(4-nitro-benzyl) ester

There total 2 articles about (Z)-(2S,8R,9R)-9-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3,6-trimethyl-10-oxo-7-oxa-4-thia-1-aza-bicyclo[6.2.0]dec-5-ene-2,5-dicarboxylic acid 2-benzyl ester 5-(4-nitro-benzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 82551-63-1
4-nitrobenzyl 2-diazo-3-oxo-butanoate

: 66363-43-7
(2S,5R,6S)-benzyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

: 86255-96-1
(Z)-(2S,8R,9R)-9-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3,6-trimethyl-10-oxo-7-oxa-4-thia-1-aza-bicyclo[6.2.0]dec-5-ene-2,5-dicarboxylic acid 2-benzyl ester 5-(4-nitro-benzyl) ester

: 86255-97-2,86288-03-1,100163-31-3
(Z)-2-[(2R,3S)-1-((R)-1-Benzyloxycarbonyl-2-methyl-allyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-4-oxo-azetidin-2-ylsulfanyl]-3-hydroxy-but-2-enoic acid 4-nitro-benzyl ester

Guidance literature:: rhodium(II) acetate; In dichloromethane; benzene; at 70 - 80 ℃;
DOI:10.1016/S0040-4039(00)81370-2

Reference yield:

: 59034-26-3
(2S,5R,6R)-benzyl 6-(1,3-dioxoisoindolin-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

: 86255-96-1
(Z)-(2S,8R,9R)-9-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3,3,6-trimethyl-10-oxo-7-oxa-4-thia-1-aza-bicyclo[6.2.0]dec-5-ene-2,5-dicarboxylic acid 2-benzyl ester 5-(4-nitro-benzyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / dimethylformamide

2: 22 percent / Rh(OAc)2 / CH₂Cl₂; benzene / 70 - 80 °C

With sodium hydride; rhodium(II) acetate; In dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4039(00)81370-2