ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate

Base Information

Chemical Name:ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate
CAS No.:1313053-02-9
Molecular Formula:C₂₆H₃₀N₂O₃
Molecular Weight:418.536
Hs Code.:

Synonyms:ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate

Suppliers and Price of ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate

There total 8 articles about ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1313053-05-2
ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-benzyloxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate

: 1313053-02-9
ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate

Guidance literature:: ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-benzyloxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate; With boron tribromide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;

With water; sodium hydrogencarbonate; In dichloromethane; Inert atmosphere;

Reference yield:

: 14472-14-1
4-bromo-3-methylphenol

: 1313053-02-9
ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanesulfonic acid / dichloromethane / 28.8 h / 85 °C

2.1: potassium carbonate / acetone / 24 h / Reflux; Inert atmosphere

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 90 °C

5.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

5.2: Inert atmosphere

With n-butyllithium; methanesulfonic acid; boron tribromide; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; water; acetone;

Reference yield:

: 140-88-5,9003-32-1
ethyl acrylate

: 1313053-02-9
ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methylphenyl)-5-pyrimidinyl]-2-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3.5 h / 115 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 20 h / 90 °C

3.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: Inert atmosphere

With boron tribromide; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; tris-(o-tolyl)phosphine; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;