(2R,3R,4R,5R)-2-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(4-methylbenzoyloxy)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydrofuran-3-ol

Base Information

Chemical Name:(2R,3R,4R,5R)-2-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(4-methylbenzoyloxy)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydrofuran-3-ol
CAS No.:1044590-06-8
Molecular Formula:C₂₉H₂₄ClN₃O₆
Molecular Weight:545.979
Hs Code.:

Synonyms:(2R,3R,4R,5R)-2-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(4-methylbenzoyloxy)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydrofuran-3-ol

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Chemical Property of (2R,3R,4R,5R)-2-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(4-methylbenzoyloxy)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydrofuran-3-ol

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Technology Process of (2R,3R,4R,5R)-2-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(4-methylbenzoyloxy)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydrofuran-3-ol

There total 3 articles about (2R,3R,4R,5R)-2-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(4-methylbenzoyloxy)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydrofuran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1044590-05-7
1,2-anhydro-2-C-ethynyl-3,5-bis(4-methylbenzoyl)-α-D-ribofuranose

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1044590-06-8
(2R,3R,4R,5R)-2-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(4-methylbenzoyloxy)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydrofuran-3-ol

Guidance literature:: 4-chloro-1H-pyrrolo[2,3-d]pyrimidine; With sodium hydride; In acetonitrile; for 0.166667h;

1,2-anhydro-2-C-ethynyl-3,5-bis(4-methylbenzoyl)-α-D-ribofuranose; In acetonitrile; at 50 ℃; for 15h;

With hydrogenchloride; In water; acetonitrile; pH=7;

Reference yield:

: (3R,4R,5R)-4-(4-methylbenzoyloxyl)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydro-furan-2,3-diol

: 1044590-06-8
(2R,3R,4R,5R)-2-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(4-methylbenzoyloxy)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 2.66 h / 30 - 40 °C

2.1: sodium hydride / acetonitrile; mineral oil / 0.17 h

2.2: 15 h / 50 °C

With sodium hydride; triethylamine; Methanesulfonic anhydride; In dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 2-C-ethynyl-2-O-(2,5-dichlorobenzyl)-3,5-bis(4-methylbenzoate)-D-ribose

: 1044590-06-8
(2R,3R,4R,5R)-2-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(4-methylbenzoyloxy)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydrofuran-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trichloride / dichloromethane / 3 h / -35 °C

1.2: 0.17 h / Cooling

2.1: triethylamine; Methanesulfonic anhydride / dichloromethane / 2.66 h / 30 - 40 °C

3.1: sodium hydride / acetonitrile; mineral oil / 0.17 h

3.2: 15 h / 50 °C

With boron trichloride; sodium hydride; triethylamine; Methanesulfonic anhydride; In dichloromethane; acetonitrile; mineral oil;