1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine

Base Information

• Chemical Name: 1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine
• CAS No.: 137915-51-6
• Molecular Formula: C₂₂H₃₂N₂O₆SSi
• Molecular Weight: 480.657

Synonyms:1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine

Chemical Property of 1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine

Chemical Property:

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Technology Process of 1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine

There total 1 articles about 1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

methyl 3-sulfanylbenzoate (72886-42-1) + 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylsulfinyl)thymine (125057-12-7) → 1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine (137915-51-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

DOI:10.1021/jm00080a020

Reference yield: 88.0%

1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine (137915-51-6) → 1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<(3-carboxyphenyl)thio>thymine (137897-76-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; ethanol; for 1h; Ambient temperature;

DOI:10.1021/jm00080a020

Reference yield: 70.0%

1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine (137915-51-6) → 1-<(2-hydroxyethoxy)methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine (137897-74-6)

Guidance literature:

With acetic acid; In tetrahydrofuran; water; for 14h; Ambient temperature;

DOI:10.1021/jm00080a020

upstream raw materials:

methyl 3-sulfanylbenzoate

1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylsulfinyl)thymine

Downstream raw materials:

1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-<(3-carboxyphenyl)thio>thymine

1-<(2-hydroxyethoxy)methyl>-6-<<3-(methoxycarbonyl)phenyl>thio>thymine

6-<(3-cyanophenyl)thio>-1-<(2-hydroxyethoxy)methyl>thymine

6-<(3-carbamoylphenyl)thio>-1-<(2-hydroxyethoxy)methyl>thymine

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