(R)-3-(2-chlorophenyl)-N-1-(naphthalene-1-yl)-propan-1-amine hydrochloride

Base Information

Chemical Name:(R)-3-(2-chlorophenyl)-N-1-(naphthalene-1-yl)-propan-1-amine hydrochloride
CAS No.:259855-87-3
Molecular Formula:C₂₁H₂₂ClN*ClH
Molecular Weight:360.326
Hs Code.:

Synonyms:(R)-3-(2-chlorophenyl)-N-1-(naphthalene-1-yl)-propan-1-amine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(2-chlorophenyl)-N-1-(naphthalene-1-yl)-propan-1-amine hydrochloride

Chemical Property:

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Technology Process of (R)-3-(2-chlorophenyl)-N-1-(naphthalene-1-yl)-propan-1-amine hydrochloride

There total 8 articles about (R)-3-(2-chlorophenyl)-N-1-(naphthalene-1-yl)-propan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: (R)-3-(2-chlorophenyl)-N-1-(naphthalene-1-yl)-propan-1-amine

: 259855-87-3
(R)-3-(2-chlorophenyl)-N-1-(naphthalene-1-yl)-propan-1-amine hydrochloride

Guidance literature:: With methanol; chloro-trimethyl-silane; In dichloromethane; at 25 ℃;
DOI:10.1021/jo400371x

Reference yield:

: 1434603-36-7
(R)-3-(2-chlorophenyl)-N-(1-naphthalen-1-ylethyl)propionamide

: 259855-87-3
(R)-3-(2-chlorophenyl)-N-1-(naphthalene-1-yl)-propan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: borane-THF / tetrahydrofuran / Inert atmosphere; Reflux

2: chloro-trimethyl-silane; methanol / dichloromethane / 25 °C

With methanol; chloro-trimethyl-silane; borane-THF; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo400371x

Reference yield:

: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

: 259855-87-3
(R)-3-(2-chlorophenyl)-N-1-(naphthalene-1-yl)-propan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 1 h / 25 °C / Inert atmosphere

1.2: 0.5 h / 25 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / Inert atmosphere; Reflux

3.1: chloro-trimethyl-silane; methanol / dichloromethane / 25 °C

With methanol; dmap; chloro-trimethyl-silane; borane-THF; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo400371x