5-Chloro-2-fluoro-4-[(1-isopropyl-1H-indazol-5-yl)oxy]-N-(methylsulfonyl)benzamide

Base Information

Chemical Name:5-Chloro-2-fluoro-4-[(1-isopropyl-1H-indazol-5-yl)oxy]-N-(methylsulfonyl)benzamide
CAS No.:1355063-65-8
Molecular Formula:C₁₈H₁₇ClFN₃O₄S
Molecular Weight:425.868
Hs Code.:

Synonyms:5-Chloro-2-fluoro-4-[(1-isopropyl-1H-indazol-5-yl)oxy]-N-(methylsulfonyl)benzamide

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Chemical Property of 5-Chloro-2-fluoro-4-[(1-isopropyl-1H-indazol-5-yl)oxy]-N-(methylsulfonyl)benzamide

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Technology Process of 5-Chloro-2-fluoro-4-[(1-isopropyl-1H-indazol-5-yl)oxy]-N-(methylsulfonyl)benzamide

There total 3 articles about 5-Chloro-2-fluoro-4-[(1-isopropyl-1H-indazol-5-yl)oxy]-N-(methylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1355066-73-7
1-isopropyl-1H-indazol-5-ol

: 1354960-67-0
5-chloro-2,4-difluoro-N-(methylsulfonyl)benzamide

: 1355063-65-8
5-Chloro-2-fluoro-4-[(1-isopropyl-1H-indazol-5-yl)oxy]-N-(methylsulfonyl)benzamide

Guidance literature:: 1-isopropyl-1H-indazol-5-ol; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.666667h; Cooling with ice;

5-chloro-2,4-difluoro-N-(methylsulfonyl)benzamide; In tetrahydrofuran; mineral oil; at 60 ℃; for 16h;

Reference yield:

: 1355066-75-9
5-{[tert-Butyl(dimethyl)silyl]oxy}-1-isopropyl-1H-indazole

: 1355063-65-8
5-Chloro-2-fluoro-4-[(1-isopropyl-1H-indazol-5-yl)oxy]-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine tris(hydrogen fluoride); methanol / 18 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / Cooling with ice

2.2: 16 h / 60 °C

With methanol; sodium hydride; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; mineral oil;

Reference yield:

: 5-chloro-2,4-difluorobenzoic acid

: 1355063-65-8
5-Chloro-2-fluoro-4-[(1-isopropyl-1H-indazol-5-yl)oxy]-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / Cooling with ice

2.2: 16 h / 60 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; mineral oil;