1-Benzyl-2-methyl-4-oxoazetidine-2-carboxylic acid

Base Information

Chemical Name:1-Benzyl-2-methyl-4-oxoazetidine-2-carboxylic acid
CAS No.:344765-41-9
Molecular Formula:C12H13 N O3
Molecular Weight:0
Hs Code.:
DSSTox Substance ID:DTXSID20443091
Nikkaji Number:J1.535.040G
Mol file:344765-41-9.mol

Synonyms:344765-41-9;1-Benzyl-2-methyl-4-oxoazetidine-2-carboxylic acid;2-Azetidinecarboxylicacid, 2-methyl-4-oxo-1-(phenylmethyl)-;DTXSID20443091

Suppliers and Price of 1-Benzyl-2-methyl-4-oxoazetidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1-Benzyl-2-methyl-4-oxoazetidine-2-carboxylic acid

Chemical Property:

PSA：57.61000
LogP:1.20010
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:219.08954328
Heavy Atom Count:16
Complexity:309

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CC(=O)N1CC2=CC=CC=C2)C(=O)O

Technology Process of 1-Benzyl-2-methyl-4-oxoazetidine-2-carboxylic acid

There total 3 articles about 1-Benzyl-2-methyl-4-oxoazetidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 344765-29-3
1-benzyl-4-tert-butoxycarbonyl-4-methyl-2-azetidinone

: 344765-41-9
1-benzyl-4-carboxy-4-methyl-2-azetidinone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo015559b

Reference yield:

: 85753-12-4
N-benzyl-L-alanine tert-butyl ester

: 344765-41-9
1-benzyl-4-carboxy-4-methyl-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / propylene oxide / tetrahydrofuran / 20 °C

2: 60 percent / NaH / acetonitrile / 24 h / 20 °C

3: 99 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With sodium hydride; trifluoroacetic acid; methyloxirane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo015559b

Reference yield:

: 344765-16-8
N-benzyl-N-chloroacetyl-L-Ala-O^tBu

: 344765-41-9
1-benzyl-4-carboxy-4-methyl-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / NaH / acetonitrile / 24 h / 20 °C

2: 99 percent / TFA / CH₂Cl₂ / 2 h / 20 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jo015559b