Ethyl 2-[4-(chloromethyl)phenyl]propanoate

Base Information

Chemical Name:Ethyl 2-[4-(chloromethyl)phenyl]propanoate
CAS No.:43153-03-3
Molecular Formula:C12H15 Cl O2
Molecular Weight:226.703
Hs Code.:2916399090
DSSTox Substance ID:DTXSID90451320
Nikkaji Number:J1.641.681I
Mol file:43153-03-3.mol

Synonyms:43153-03-3;Ethyl 2-[4-(chloromethyl)phenyl]propanoate;2-(4-CHLOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER;4-(Chloromethyl)-alpha-methyl-benzeneacetic Acid Ethyl Ester;2-(4-chloromethylphenyl)Propanoic acid ethyl ester;2-(4-chloromethylphenyl)propionic acid ethyl ester;SCHEMBL7625059;DTXSID90451320;LJRSKOFNPMYRSO-UHFFFAOYSA-N;AKOS022182262;ethyl 2-(4-chloromethylphenyl)propionate;ethyl 2-(p-chloromethylphenyl)propionate;AS-68974;Ethyl2-[4-(chloromethyl)phenyl]propanoate;FT-0664776;D93480;J-505940

Suppliers and Price of Ethyl 2-[4-(chloromethyl)phenyl]propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(Chloromethyl)-α-methyl-benzeneaceticAcidEthylEster
10mg
$ 165.00

Biosynth Carbosynth
4-(Chloromethyl)-a-methyl-benzeneacetic acid ethyl ester
5 mg
$ 150.00

Biosynth Carbosynth
4-(Chloromethyl)-a-methyl-benzeneacetic acid ethyl ester
100 mg
$ 1638.00

Biosynth Carbosynth
4-(Chloromethyl)-a-methyl-benzeneacetic acid ethyl ester
50 mg
$ 901.00

Biosynth Carbosynth
4-(Chloromethyl)-a-methyl-benzeneacetic acid ethyl ester
25 mg
$ 496.00

Biosynth Carbosynth
4-(Chloromethyl)-a-methyl-benzeneacetic acid ethyl ester
10 mg
$ 272.60

Total 25 raw suppliers

Chemical Property of Ethyl 2-[4-(chloromethyl)phenyl]propanoate

Chemical Property:

Boiling Point:303.8±22.0 °C(Predicted)
PSA：26.30000
Density:1.112±0.06 g/cm3(Predicted)
LogP:3.09200
Solubility.:Chloroform, Dichloromethane, Ethyl Acetate
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:226.0760574
Heavy Atom Count:15
Complexity:198

Purity/Quality:

97% ^*data from raw suppliers

4-(Chloromethyl)-α-methyl-benzeneaceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C)C1=CC=C(C=C1)CCl
Uses 2-(4-chloromethyl-phenyl)-propionic acid ethyl ester can be used in the preparation of Ibuprofen impurities and derivatives.

Technology Process of Ethyl 2-[4-(chloromethyl)phenyl]propanoate

There total 6 articles about Ethyl 2-[4-(chloromethyl)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 118618-33-0
ethyl 2--propionate

: 43153-03-3
2-(4-chloromethylphenyl)-propionic ethyl ester

Guidance literature:: With hydrogenchloride; for 0.5h; Ambient temperature;

Reference yield:

: 32868-25-0
2-(4-amminofenil)propionico d'etile

: 43153-03-3
2-(4-chloromethylphenyl)-propionic ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaNO₂; 2.) K₂CO₃; 3.) CuCN / 1.) 6M HCl, H₂O, 0-5 deg C, 15 min; 2.) 0-5 deg C; 3.) water, 110 deg C, 25 min

2: 57 percent / Raney-alloy / formic acid / 1 h / Heating

3: 88 percent / NaBH₄ / methanol; H₂O / 20 - 22 °C

4: 92 percent / 12M HCl / 0.5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; Raney-alloy; potassium carbonate; sodium nitrite; In methanol; formic acid; water;

Reference yield:

: 43153-04-4
ethyl 2-(4-formylphenyl)propionate

: 43153-03-3
2-(4-chloromethylphenyl)-propionic ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / NaBH₄ / methanol; H₂O / 20 - 22 °C

2: 92 percent / 12M HCl / 0.5 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; In methanol; water;