-(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide

Base Information

Chemical Name:-(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide
CAS No.:157020-40-1
Molecular Formula:C₁₇H₂₀N₄O₂S
Molecular Weight:344.437
Hs Code.:

<R-(Z)>-(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide

Synonyms:-(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide

Suppliers and Price of -(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of -(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of -(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide

There total 13 articles about -(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: C₁₇H₂₀ClNO₂S

: 157020-40-1
-(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide

Guidance literature:: With sodium azide; In water; acetone; for 12h; Ambient temperature;
DOI:10.1021/jo00107a009

Reference yield:

: 50889-29-7
(5-carboxypentyl)triphenylphosphonium bromide

: 157020-40-1
-(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide

Guidance literature:: Multi-step reaction with 8 steps

1: 78 percent / LDA / tetrahydrofuran; hexane / 1.) room temp., 30 min, 2.) room temp, 1 h

2: 95 percent / Na, NH₃(l) / 2 h

3: 24 percent / phenyl dichlorophosphate, DMF, pyridine / CH₂Cl₂ / 22 h / Ambient temperature

4: 98 percent / HCl(g) / diethyl ether / 0.5 h / 0 °C

5: 80 percent / aq. NaHCO₃, MgSO₄ / CH₂Cl₂ / 3 h / Ambient temperature

6: 69 percent / NaCNBH₃, buffer: citric acid pH 4 / tetrahydrofuran / 0.67 h / 0 °C

7: 100 percent / DBU / CH₂Cl₂ / 3.5 h / 0 °C

8: 72 percent / NaN₃ / acetone; H₂O / 12 h / Ambient temperature

With pyridine; hydrogenchloride; sodium azide; buffer: citric acid pH 4; ammonia; sodium; sodium cyanoborohydride; sodium hydrogencarbonate; magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; O-phenyl phosphorodichloridate; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; acetone;
DOI:10.1021/jo00107a009

Reference yield:

: 157020-37-6
1,1-Dimethylethyl -(3,6,7,8,9,10-hexahydro-10-oxo-2H-thiecin-3-yl)carbamate

: 157020-40-1
-(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / HCl(g) / diethyl ether / 0.5 h / 0 °C

2: 80 percent / aq. NaHCO₃, MgSO₄ / CH₂Cl₂ / 3 h / Ambient temperature

3: 69 percent / NaCNBH₃, buffer: citric acid pH 4 / tetrahydrofuran / 0.67 h / 0 °C

4: 100 percent / DBU / CH₂Cl₂ / 3.5 h / 0 °C

5: 72 percent / NaN₃ / acetone; H₂O / 12 h / Ambient temperature

With hydrogenchloride; sodium azide; buffer: citric acid pH 4; sodium cyanoborohydride; sodium hydrogencarbonate; magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetone;
DOI:10.1021/jo00107a009