(S)-N-(ethoxycarbonyl)-3-(4-(trifluoromethyl)phenoxy)-3-phenyl-1-propanamine

Base Information

Chemical Name:(S)-N-(ethoxycarbonyl)-3-(4-(trifluoromethyl)phenoxy)-3-phenyl-1-propanamine
CAS No.:191733-30-9
Molecular Formula:C₁₉H₂₀F₃NO₃
Molecular Weight:367.368
Hs Code.:

Synonyms:(S)-N-(ethoxycarbonyl)-3-(4-(trifluoromethyl)phenoxy)-3-phenyl-1-propanamine

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Chemical Property of (S)-N-(ethoxycarbonyl)-3-(4-(trifluoromethyl)phenoxy)-3-phenyl-1-propanamine

Chemical Property:

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Technology Process of (S)-N-(ethoxycarbonyl)-3-(4-(trifluoromethyl)phenoxy)-3-phenyl-1-propanamine

There total 5 articles about (S)-N-(ethoxycarbonyl)-3-(4-(trifluoromethyl)phenoxy)-3-phenyl-1-propanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 402-45-9
4-hydroxybenzotrifluoride

: 502697-62-3
(R)-(3-hydroxy-3-phenylpropyl)carbamic acid ethyl ester

: 191733-30-9
(S)-N-(ethoxycarbonyl)-3-(4-(trifluoromethyl)phenoxy)-3-phenyl-1-propanamine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In diethyl ether; at 0 - 20 ℃; for 2h;
DOI:10.1016/S0957-4166(02)00537-2

Reference yield:

: 96-09-3
styrene oxide

: 191733-30-9
(S)-N-(ethoxycarbonyl)-3-(4-(trifluoromethyl)phenoxy)-3-phenyl-1-propanamine

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / ethanol; H₂O / 20 °C

2: 46 percent / Pseudomonas cepacia lipase on modified ceramic particles / diisopropyl ether / 16 h / 27 °C

3: 88 percent / BH₃*SMe₂ / tetrahydrofuran / Heating

4: 88 percent / K₂CO₃ / CH₂Cl₂; H₂O / 20 °C

5: 71 percent / diisopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 2 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; dimethylsulfide borane complex; Pseudomonas cepacia lipase on modified ceramic particles; potassium carbonate; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; di-isopropyl ether; water; 5: Mitsunobu coupling;
DOI:10.1016/S0957-4166(02)00537-2

Reference yield:

: 73627-97-1,121617-17-2,132203-26-0,17190-29-3
3-hydroxy-3-phenylpropanenitrile

: 191733-30-9
(S)-N-(ethoxycarbonyl)-3-(4-(trifluoromethyl)phenoxy)-3-phenyl-1-propanamine

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / Pseudomonas cepacia lipase on modified ceramic particles / diisopropyl ether / 16 h / 27 °C

2: 88 percent / BH₃*SMe₂ / tetrahydrofuran / Heating

3: 88 percent / K₂CO₃ / CH₂Cl₂; H₂O / 20 °C

4: 71 percent / diisopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 2 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; dimethylsulfide borane complex; Pseudomonas cepacia lipase on modified ceramic particles; potassium carbonate; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; di-isopropyl ether; water; 4: Mitsunobu coupling;
DOI:10.1016/S0957-4166(02)00537-2