4-(3-methoxyphenoxy)-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine

Base Information

• Chemical Name: 4-(3-methoxyphenoxy)-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine
• CAS No.: 1450980-10-5
• Molecular Formula: C₂₀H₁₆N₂O₃S
• Molecular Weight: 364.425
• Mol file: 1450980-10-5.mol

Synonyms:4-(3-methoxyphenoxy)-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine

Chemical Property of 4-(3-methoxyphenoxy)-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-methoxyphenoxy)-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine

There total 4 articles about 4-(3-methoxyphenoxy)-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-chloro-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine (874818-64-1) + sodium 3-methoxyphenolate (51113-99-6) → 4-(3-methoxyphenoxy)-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine (1450980-10-5)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.3390/molecules18044487

Reference yield:

3-amino-5-(3-methoxyphenyl)thiophene-2-carboxamide (354811-98-6) → 4-(3-methoxyphenoxy)-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine (1450980-10-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 50 °C

2: trichlorophosphate / 0.33 h / 95 °C / Microwave irradiation

3: N,N-dimethyl-formamide / 2 h / 20 °C

With sulfuric acid; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.3390/molecules18044487

Reference yield:

3-chloro-3-(3-methoxyphenyl)prop-2-enenitrile (474843-37-3) → 4-(3-methoxyphenoxy)-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine (1450980-10-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodiumsulfide nonahydrate / N,N-dimethyl-formamide / 2 h / 50 °C

1.2: 50 °C

2.1: sulfuric acid / 50 °C

3.1: trichlorophosphate / 0.33 h / 95 °C / Microwave irradiation

4.1: N,N-dimethyl-formamide / 2 h / 20 °C

With sodiumsulfide nonahydrate; sulfuric acid; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.3390/molecules18044487

upstream raw materials:

3-amino-5-(3-methoxyphenyl)thiophene-2-carboxamide

6-(3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

4-chloro-6-(3-methoxyphenyl)thieno[3,2-d]pyrimidine

sodium 3-methoxyphenolate