(4R,6S)-4-Hydroxy-6-{(1R,2S)-2-methoxy-3-[(2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-1-methyl-propyl}-tetrahydro-pyran-2-one

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Chemical Name:(4R,6S)-4-Hydroxy-6-{(1R,2S)-2-methoxy-3-[(2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-1-methyl-propyl}-tetrahydro-pyran-2-one
CAS No.:145823-00-3
Molecular Formula:C₂₁H₃₀O₇
Molecular Weight:394.465
Hs Code.:

Synonyms:(4R,6S)-4-Hydroxy-6-{(1R,2S)-2-methoxy-3-[(2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-1-methyl-propyl}-tetrahydro-pyran-2-one

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Chemical Property of (4R,6S)-4-Hydroxy-6-{(1R,2S)-2-methoxy-3-[(2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-1-methyl-propyl}-tetrahydro-pyran-2-one

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Technology Process of (4R,6S)-4-Hydroxy-6-{(1R,2S)-2-methoxy-3-[(2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-1-methyl-propyl}-tetrahydro-pyran-2-one

There total 15 articles about (4R,6S)-4-Hydroxy-6-{(1R,2S)-2-methoxy-3-[(2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-1-methyl-propyl}-tetrahydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: (3S,5S,6S,7S)-7-Methoxy-8-[(2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-6-methyl-octane-1,3,5-triol

: 145823-00-3
(4R,6S)-4-Hydroxy-6-{(1R,2S)-2-methoxy-3-[(2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-1-methyl-propyl}-tetrahydro-pyran-2-one

Guidance literature:: With silver carbonate; In benzene; Heating;
DOI:10.1016/0040-4039(94)88288-6

Reference yield:

: 127760-85-4
(S)-5-Benzyloxy-3-(tetrahydro-pyran-2-yloxy)-pentanal

: 145823-00-3
(4R,6S)-4-Hydroxy-6-{(1R,2S)-2-methoxy-3-[(2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-1-methyl-propyl}-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 15 steps

1: 90 percent / triethylamine / 5 h / 4125330 Torr / Ambient temperature

2: AcOH / H₂O / Ambient temperature

3: CSA / acetone / Ambient temperature

4: t-BuONa, KMnO₄, MgSO₄ / H₂O; benzene / Ambient temperature

5: K₂CO₃ / methanol / Ambient temperature

6: 98 percent / n-BuLi / tetrahydrofuran / Ambient temperature

7: 1.) AcOH, 2.) CSA / 1.) H₂O, room temperature, 2.) CH₂Cl₂, room temperature

8: 1.) BH₃*Me₂S, 2.) 15percent NaOH, 30percent H₂O₂ / 1.) THF, room temperature, 2.) room temperature

9: 81 percent / pyridine / Ambient temperature

10: LiAlH₄ / diethyl ether / 0 °C

11: KH / tetrahydrofuran / 0 °C

12: H₂ / Raney Ni / ethanol / Ambient temperature

13: AcOH / H₂O / Ambient temperature

14: DDQ / CH₂Cl₂ / Ambient temperature

15: 51 percent / Ag₂CO₃-celite / benzene / Heating

With sodium hydroxide; potassium permanganate; lithium aluminium tetrahydride; n-butyllithium; dimethylsulfide borane complex; camphor-10-sulfonic acid; hydrogen; dihydrogen peroxide; potassium hydride; magnesium sulfate; potassium carbonate; acetic acid; silver carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium t-butanolate; nickel; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water; triethylamine; acetone; benzene;
DOI:10.1016/0040-4039(94)88288-6

Reference yield:

: (3S,9S)-1,11-Bis-benzyloxy-6-nitro-undecane-3,5,7,9-tetraol

: 145823-00-3
(4R,6S)-4-Hydroxy-6-{(1R,2S)-2-methoxy-3-[(2S,4S)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-1-methyl-propyl}-tetrahydro-pyran-2-one

Guidance literature:: Multi-step reaction with 13 steps

1: CSA / acetone / Ambient temperature

2: t-BuONa, KMnO₄, MgSO₄ / H₂O; benzene / Ambient temperature

3: K₂CO₃ / methanol / Ambient temperature

4: 98 percent / n-BuLi / tetrahydrofuran / Ambient temperature

5: 1.) AcOH, 2.) CSA / 1.) H₂O, room temperature, 2.) CH₂Cl₂, room temperature

6: 1.) BH₃*Me₂S, 2.) 15percent NaOH, 30percent H₂O₂ / 1.) THF, room temperature, 2.) room temperature

7: 81 percent / pyridine / Ambient temperature

8: LiAlH₄ / diethyl ether / 0 °C

9: KH / tetrahydrofuran / 0 °C

10: H₂ / Raney Ni / ethanol / Ambient temperature

11: AcOH / H₂O / Ambient temperature

12: DDQ / CH₂Cl₂ / Ambient temperature

13: 51 percent / Ag₂CO₃-celite / benzene / Heating

With sodium hydroxide; potassium permanganate; lithium aluminium tetrahydride; n-butyllithium; dimethylsulfide borane complex; camphor-10-sulfonic acid; hydrogen; dihydrogen peroxide; potassium hydride; magnesium sulfate; potassium carbonate; acetic acid; silver carbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium t-butanolate; nickel; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water; acetone; benzene;
DOI:10.1016/0040-4039(94)88288-6