benzyl 4-(2-{3-[(E)-3-ethoxy-3-oxo-1-propenyl]-1H-1-indolyl}-ethyl)-1-piperidinecarboxylate

Base Information

Chemical Name:benzyl 4-(2-{3-[(E)-3-ethoxy-3-oxo-1-propenyl]-1H-1-indolyl}-ethyl)-1-piperidinecarboxylate
CAS No.:461052-29-9
Molecular Formula:C₂₈H₃₂N₂O₄
Molecular Weight:460.573
Hs Code.:

Synonyms:benzyl 4-(2-{3-[(E)-3-ethoxy-3-oxo-1-propenyl]-1H-1-indolyl}-ethyl)-1-piperidinecarboxylate

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Chemical Property of benzyl 4-(2-{3-[(E)-3-ethoxy-3-oxo-1-propenyl]-1H-1-indolyl}-ethyl)-1-piperidinecarboxylate

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Technology Process of benzyl 4-(2-{3-[(E)-3-ethoxy-3-oxo-1-propenyl]-1H-1-indolyl}-ethyl)-1-piperidinecarboxylate

There total 4 articles about benzyl 4-(2-{3-[(E)-3-ethoxy-3-oxo-1-propenyl]-1H-1-indolyl}-ethyl)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 461052-27-7
4-[2-(3-formyl-indol-1-yl)-ethyl]-piperidine-1-carboxylic acid benzyl ester

: 461052-29-9
benzyl 4-(2-{3-[(E)-3-ethoxy-3-oxo-1-propenyl]-1H-1-indolyl}-ethyl)-1-piperidinecarboxylate

Guidance literature:: In toluene; for 17h; Heating;
DOI:10.1016/S0223-5234(01)01325-3

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 461052-29-9
benzyl 4-(2-{3-[(E)-3-ethoxy-3-oxo-1-propenyl]-1H-1-indolyl}-ethyl)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / K₂CO₃ / acetonitrile / 24 h / Heating

2: 87 percent / toluene / 17 h / Heating

With potassium carbonate; In toluene; acetonitrile; 2: Wittig reaction;
DOI:10.1016/S0223-5234(01)01325-3

Reference yield:

: 115909-91-6
1-(Benzyloxycarbonyl)-4-(2-hydroxyethyl)piperidine

: 461052-29-9
benzyl 4-(2-{3-[(E)-3-ethoxy-3-oxo-1-propenyl]-1H-1-indolyl}-ethyl)-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / triphenylphosphine; imidazole; iodine / toluene; acetonitrile / 3 h / 20 °C

2: 99 percent / K₂CO₃ / acetonitrile / 24 h / Heating

3: 87 percent / toluene / 17 h / Heating

With 1H-imidazole; iodine; potassium carbonate; triphenylphosphine; In toluene; acetonitrile; 3: Wittig reaction;
DOI:10.1016/S0223-5234(01)01325-3