(S)-3-[(S)-2-chlorosulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester

Base Information

Chemical Name:(S)-3-[(S)-2-chlorosulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester
CAS No.:1380182-97-7
Molecular Formula:C₁₈H₂₃ClF₃NO₅S
Molecular Weight:457.899
Hs Code.:

Synonyms:(S)-3-[(S)-2-chlorosulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester

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Chemical Property of (S)-3-[(S)-2-chlorosulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester

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Technology Process of (S)-3-[(S)-2-chlorosulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester

There total 7 articles about (S)-3-[(S)-2-chlorosulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₆F₃NO₄S

: 1380182-97-7
(S)-3-[(S)-2-chlorosulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: With hydrogenchloride; N-chloro-succinimide; water; In acetonitrile; at 0 ℃; for 1h;

Reference yield:

: 1228312-14-8
(R)-3-vinylpyrrolidine-1-carboxylic acid t-butyl ester

: 1380182-97-7
(S)-3-[(S)-2-chlorosulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: dihydrogen peroxide / pyridine-3-carbonitrile; methyltrioxorhenium(VII) / water / 2 h / Cooling with ice

2.1: sodium hydride / 50 °C / Inert atmosphere

2.2: 50 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 3.17 h / 20 - 90 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / methanol / 760.05 Torr

5.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 1 h / 0 - 20 °C

6.1: ethanol / 72 h / 50 °C

7.1: N-chloro-succinimide; hydrogenchloride; water / acetonitrile / 1 h / 0 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; N-chloro-succinimide; water; hydrogen; dihydrogen peroxide; sodium hydride; pyridine-3-carbonitrile; palladium 10% on activated carbon; methyltrioxorhenium(VII); In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1262116-18-6
(S)-(S)-3-oxiranylpyrrolidine-1-carboxylic acid t-butyl ester

: 1380182-97-7
(S)-3-[(S)-2-chlorosulfonyl-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / 50 °C / Inert atmosphere

1.2: 50 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 3.17 h / 20 - 90 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 760.05 Torr

4.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 1 h / 0 - 20 °C

5.1: ethanol / 72 h / 50 °C

6.1: N-chloro-succinimide; hydrogenchloride; water / acetonitrile / 1 h / 0 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; N-chloro-succinimide; water; hydrogen; sodium hydride; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;