4-[4-(1,3-benzoxazol-2-yl)naphtho[1,2-d][1,3]oxazol-2-yl]phenol

Base Information

• Chemical Name: 4-[4-(1,3-benzoxazol-2-yl)naphtho[1,2-d][1,3]oxazol-2-yl]phenol
• CAS No.: 1432475-88-1
• Molecular Formula: C₂₄H₁₄N₂O₃
• Molecular Weight: 378.387
• Mol file: 1432475-88-1.mol

Synonyms:4-[4-(1,3-benzoxazol-2-yl)naphtho[1,2-d][1,3]oxazol-2-yl]phenol

Chemical Property of 4-[4-(1,3-benzoxazol-2-yl)naphtho[1,2-d][1,3]oxazol-2-yl]phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-(1,3-benzoxazol-2-yl)naphtho[1,2-d][1,3]oxazol-2-yl]phenol

There total 6 articles about 4-[4-(1,3-benzoxazol-2-yl)naphtho[1,2-d][1,3]oxazol-2-yl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-amino-3-(1,3-benzoxazol-2-yl)naphthalen-2-ol (1418220-62-8) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-[4-(1,3-benzoxazol-2-yl)naphtho[1,2-d][1,3]oxazol-2-yl]phenol (1432475-88-1)

Guidance literature:

In dimethyl sulfoxide; at 158 - 160 ℃; for 10.5h;

DOI:10.1007/s12039-012-0324-3

Reference yield: 57.0%

1-amino-3-(1,3-benzoxazol-2-yl)naphthalen-2-ol (1418220-62-8) + 4-hydroxy-benzoic acid (99-96-7) → 4-[4-(1,3-benzoxazol-2-yl)naphtho[1,2-d][1,3]oxazol-2-yl]phenol (1432475-88-1)

Guidance literature:

With phosphorus trichloride; In chlorobenzene; at 130 - 133 ℃; for 16h;

DOI:10.1007/s12039-012-0324-3

Reference yield:

3-Hydroxy-2-naphthoic acid (92-70-6) → 4-[4-(1,3-benzoxazol-2-yl)naphtho[1,2-d][1,3]oxazol-2-yl]phenol (1432475-88-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: phosphorus trichloride / chlorobenzene / 4 h / 133 - 135 °C

2.1: sodium carbonate; sodium nitrite; hydrogenchloride / water / 2 h / 0 - 55 °C

2.2: 4 h / 0 - 20 °C / pH 8 - 9

3.1: sodium hydroxide; sodium dithionite / water / 2.5 h / 50 - 90 °C / pH 8 - 9

4.1: phosphorus trichloride / chlorobenzene / 16 h / 130 - 133 °C

With hydrogenchloride; sodium dithionite; sodium carbonate; sodium hydroxide; sodium nitrite; phosphorus trichloride; In water; chlorobenzene;

DOI:10.1007/s12039-012-0324-3

upstream raw materials:

1-amino-3-(1,3-benzoxazol-2-yl)naphthalen-2-ol

4-hydroxy-benzoic acid

4-hydroxy-benzaldehyde

2-amino-phenol