(R)-N-(1-phenylethyl)-6-(2,4,6-tri-isopropylphenyl)thieno[2,3-d]pyrimidin-4-amine

Base Information

Chemical Name:(R)-N-(1-phenylethyl)-6-(2,4,6-tri-isopropylphenyl)thieno[2,3-d]pyrimidin-4-amine
CAS No.:1408055-36-6
Molecular Formula:C₂₉H₃₅N₃S
Molecular Weight:457.683
Hs Code.:

Synonyms:(R)-N-(1-phenylethyl)-6-(2,4,6-tri-isopropylphenyl)thieno[2,3-d]pyrimidin-4-amine

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Chemical Property of (R)-N-(1-phenylethyl)-6-(2,4,6-tri-isopropylphenyl)thieno[2,3-d]pyrimidin-4-amine

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Technology Process of (R)-N-(1-phenylethyl)-6-(2,4,6-tri-isopropylphenyl)thieno[2,3-d]pyrimidin-4-amine

There total 5 articles about (R)-N-(1-phenylethyl)-6-(2,4,6-tri-isopropylphenyl)thieno[2,3-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-6-bromo-N-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine hydrochloride

: 154549-38-9
2,4,6-triisopropylphenylboronic acid

: 1408055-36-6
(R)-N-(1-phenylethyl)-6-(2,4,6-tri-isopropylphenyl)thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 22h; Inert atmosphere;
DOI:10.1016/j.tet.2012.08.090

Reference yield:

: 14080-50-3
thieno[2,3-d]pyrimidin-4(3H)one

: 1408055-36-6
(R)-N-(1-phenylethyl)-6-(2,4,6-tri-isopropylphenyl)thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; bromine / 3 h / 80 °C

2: trichlorophosphate / 3 h / 120 °C

3: butan-1-ol / 15 h / 145 °C

4: hydrogenchloride / diethyl ether / 29 h / -18 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 22 h / 110 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; diethyl ether; water; butan-1-ol; 5: |Suzuki Coupling;
DOI:10.1016/j.tet.2012.08.090

Reference yield:

: 56844-40-7
6-bromothieno[2,3-d]pyrimidin-4(3H)-one

: 1408055-36-6
(R)-N-(1-phenylethyl)-6-(2,4,6-tri-isopropylphenyl)thieno[2,3-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / 120 °C

2: butan-1-ol / 15 h / 145 °C

3: hydrogenchloride / diethyl ether / 29 h / -18 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 22 h / 110 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; trichlorophosphate; In 1,4-dioxane; diethyl ether; water; butan-1-ol; 4: |Suzuki Coupling;
DOI:10.1016/j.tet.2012.08.090