2-(2-N-hydroxyamidino-3,4-dihydronaphthalen-7-yl)-5-(4-N-hydroxyamidinophenyl)furan

Base Information

Chemical Name:2-(2-N-hydroxyamidino-3,4-dihydronaphthalen-7-yl)-5-(4-N-hydroxyamidinophenyl)furan
CAS No.:914336-50-8
Molecular Formula:C₂₂H₂₀N₄O₃
Molecular Weight:388.426
Hs Code.:

Synonyms:2-(2-N-hydroxyamidino-3,4-dihydronaphthalen-7-yl)-5-(4-N-hydroxyamidinophenyl)furan

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-N-hydroxyamidino-3,4-dihydronaphthalen-7-yl)-5-(4-N-hydroxyamidinophenyl)furan

Chemical Property:

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Technology Process of 2-(2-N-hydroxyamidino-3,4-dihydronaphthalen-7-yl)-5-(4-N-hydroxyamidinophenyl)furan

There total 10 articles about 2-(2-N-hydroxyamidino-3,4-dihydronaphthalen-7-yl)-5-(4-N-hydroxyamidinophenyl)furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 914262-79-6
2-(2-cyano-3,4-dihydronaphthalen-7-yl)-5-(4-cyanophenyl)furan

: 914336-50-8
2-(2-N-hydroxyamidino-3,4-dihydronaphthalen-7-yl)-5-(4-N-hydroxyamidinophenyl)furan

Guidance literature:: With hydroxylamine hydrochloride; potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃;
DOI:10.1016/j.bmc.2006.07.024

Reference yield:

: 914262-77-4
7-bromo-2-cyano-3,4-dihydronaphthalene

: 914336-50-8
2-(2-N-hydroxyamidino-3,4-dihydronaphthalen-7-yl)-5-(4-N-hydroxyamidinophenyl)furan

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / tetrakis(triphenylphosphine)palladium / dioxane / 3 h / Heating

2: 35 percent / potassium acetate / tetrakis(triphenylphosphine)palladium / dimethylformamide / 120 °C

3: 87 percent / hydroxylamine hydrochloride; potassium tert-butoxide / dimethylsulfoxide / 20 °C

With hydroxylamine hydrochloride; potassium tert-butylate; potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Stille coupling / 2: Heck reaction;
DOI:10.1016/j.bmc.2006.07.024

Reference yield:

: 914262-76-3
7-bromo-2-hydroxymethyl-3,4-dihydronaphthalene

: 914336-50-8
2-(2-N-hydroxyamidino-3,4-dihydronaphthalen-7-yl)-5-(4-N-hydroxyamidinophenyl)furan

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / ammonia; magnesium sulfate; manganese(IV) oxide / propan-2-ol; tetrahydrofuran / 20 °C

2: 70 percent / tetrakis(triphenylphosphine)palladium / dioxane / 3 h / Heating

3: 35 percent / potassium acetate / tetrakis(triphenylphosphine)palladium / dimethylformamide / 120 °C

4: 87 percent / hydroxylamine hydrochloride; potassium tert-butoxide / dimethylsulfoxide / 20 °C

With manganese(IV) oxide; hydroxylamine hydrochloride; potassium tert-butylate; ammonia; potassium acetate; magnesium sulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; 2: Stille coupling / 3: Heck reaction;
DOI:10.1016/j.bmc.2006.07.024