3-chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol

Base Information

Chemical Name:3-chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol
CAS No.:1620514-84-2
Molecular Formula:C₂₂H₂₉ClN₆OS
Molecular Weight:461.031
Hs Code.:

Synonyms:3-chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol

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Chemical Property of 3-chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol

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Technology Process of 3-chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol

There total 7 articles about 3-chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1620514-82-0
5-(2-chloro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine

: 1620514-84-2
3-chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol

Guidance literature:: With palladium diacetate; acetophenone; In acetic anhydride; acetic acid; at 80 ℃; for 48h;

Reference yield:

: 1157723-14-2
5-(4-bromo-2-chlorophenyl)-1,3,4-thiadiazol-2-amine

: 1620514-84-2
3-chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 18 h / 20 °C / Inert atmosphere

2: 1-methyl-pyrrolidin-2-one / 3 h / 120 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 80 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4: palladium diacetate; acetophenone / acetic anhydride; acetic acid / 48 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; palladium diacetate; sodium carbonate; acetophenone; copper(ll) bromide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; acetic anhydride; acetic acid; acetonitrile;

Reference yield:

: 1620515-81-2
5-(4-bromo-2-chlorophenyl)-N-methyl-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine

: 1620514-84-2
3-chloro-2-(5-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,3,4-thiadiazol-2-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 80 °C / Inert atmosphere; Sealed tube; Microwave irradiation

2: palladium diacetate; acetophenone / acetic anhydride; acetic acid / 48 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; sodium carbonate; acetophenone; In 1,4-dioxane; water; acetic anhydride; acetic acid;