(2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)-4-hydroxypyrrolidine-1-carboxylate

Base Information

Chemical Name:(2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)-4-hydroxypyrrolidine-1-carboxylate
CAS No.:910448-03-2
Molecular Formula:C₃₂H₄₈N₂O₆Si
Molecular Weight:584.828
Hs Code.:

Synonyms:(2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)-4-hydroxypyrrolidine-1-carboxylate

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Chemical Property of (2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)-4-hydroxypyrrolidine-1-carboxylate

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Technology Process of (2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)-4-hydroxypyrrolidine-1-carboxylate

There total 1 articles about (2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)-4-hydroxypyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 910447-81-3
(2R,4R)-tert-butyl 4-(allyloxy)-2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)pyrrolidine-1-carboxylate

: 910448-03-2
(2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)-4-hydroxypyrrolidine-1-carboxylate

Guidance literature:: (2R,4R)-tert-butyl 4-(allyloxy)-2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)pyrrolidine-1-carboxylate; Wilkinson's catalyst; In ethanol; water; at 95 ℃; for 16h;

With potassium permanganate; In methanol; ethanol; water; at 20 ℃; for 16h;

Reference yield: 94.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 910448-03-2
(2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)-4-hydroxypyrrolidine-1-carboxylate

: 910448-04-3
C₃₃H₅₀N₂O₈SSi

Guidance literature:: With N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethyl acetate; toluene; at 20 - 60 ℃; for 5.17h;

Reference yield: 94.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 910448-03-2
(2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)-4-hydroxypyrrolidine-1-carboxylate

: (2R,4S)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-phenylpropyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylat

Guidance literature:: With N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 20 - 60 ℃; for 5h;