(R)-tert-butyl 2-[(R)-1-hydroxy-3-phenylpropyl]-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 2-[(R)-1-hydroxy-3-phenylpropyl]-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1173199-96-6
Molecular Formula:C₁₉H₂₇NO₃
Molecular Weight:317.428
Hs Code.:

Synonyms:(R)-tert-butyl 2-[(R)-1-hydroxy-3-phenylpropyl]-5,6-dihydropyridine-1(2H)-carboxylate

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Chemical Property of (R)-tert-butyl 2-[(R)-1-hydroxy-3-phenylpropyl]-5,6-dihydropyridine-1(2H)-carboxylate

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Technology Process of (R)-tert-butyl 2-[(R)-1-hydroxy-3-phenylpropyl]-5,6-dihydropyridine-1(2H)-carboxylate

There total 4 articles about (R)-tert-butyl 2-[(R)-1-hydroxy-3-phenylpropyl]-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 104-53-0
3-phenyl-propionaldehyde

: 1386393-97-0
tert-butyl 4-[(1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate

: 25015-63-8
4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

: 1173199-96-6
(R)-tert-butyl 2-[(R)-1-hydroxy-3-phenylpropyl]-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: tert-butyl 4-[(1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; With palladium diacetate; N-ethyl-N,N-diisopropylamine; bis[2-(diphenylphosphino)phenyl] ether; In diethyl ether; at 20 ℃; for 16h; Inert atmosphere;

3-phenyl-propionaldehyde; In toluene; at 20 ℃; for 16h; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c6ob00685j

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1173199-96-6
(R)-tert-butyl 2-[(R)-1-hydroxy-3-phenylpropyl]-5,6-dihydropyridine-1(2H)-carboxylate

: C₁₉H₂₇NO₃

Guidance literature:: Multi-step reaction with 2 steps

1: (S)-(-)-[(S)-2-diphenylphosphinoferrocenyl](N,N-dimethylamino)(2-diphenylphosphinophenyl)methane; palladium diacetate; N,N-dimethyl-aniline / 1,4-dioxane / 4 h / 20 °C / Inert atmosphere

2: toluene / 2 h / 130 °C / Inert atmosphere; Microwave irradiation

With (S)-(-)-[(S)-2-diphenylphosphinoferrocenyl](N,N-dimethylamino)(2-diphenylphosphinophenyl)methane; palladium diacetate; N,N-dimethyl-aniline; In 1,4-dioxane; toluene;
DOI:10.1021/ja903946f